Voriconazole Antifungal Drug Level
Label Mnemonic: VORI
Epic Lab Code: LAB4267
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Draw blood in a plain red-top tube(s). Spin down and send 2 mL of serum frozen in plastic vial.

Absolute Minimum: 0.6 mL
Turn Around Time:
2 days upon receipt at reference laboratory
Reference Range:
1.0-5.5 mcg/mL Trough level (i.e., immediately before the next dose) monitoring is recommended.
Interpretive Data:
Trough levels >6 mcg/mL (and especially >10 mcg/mL) have been associated with toxicity in several reports. Trough levels <1 mcg/mL have been associated with suboptimal response in several reports. Cautions: Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit CYP2C19 or by genetic polymorphisms that affect enzyme activity.
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CPT Code:
82542