Varicella-Zoster Ab, IgM
Label Mnemonic: VZMCSF
Epic Lab Code: LAB4229
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
CSF
Collection Medium:
CSF collection kit
Minimum:
Preferred Minimum: 0.5 mL
Absolute Minimum: 0.3 mL
Rejection Criteria:
Specimen types other than CSF. Contaminated or heat-inactivated specimens.
Turn Around Time:
1-5 days upon receipt at reference laboratory
Reference Range:
0.90 ISR or less: Negative - No significant level of IgM antibody to varicella-zoster virus detected. 0.91-1.09 ISR: Equivocal - Repeat testing in 10-14 days may be helpful. 1.10 ISR or greater: Positive - Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Interpretive Data:
The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Test Limitations:
The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Methodology:
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code:
86787