Myositis Specific Antibody Profile
Label Mnemonic: MABCP
Epic Lab Code: LAB3674
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
3 mL serum
Turn Around Time:
2 weeks upon receipt at reference laboratory
Reference Range:
Mi-2, PL-12, PL-7, EJ, OJ, SRP, Ku, U2 snRNP Reference Range: Negative Anti-PM/Scl Ab, Anti-Jo-1 Ab Reference Range: <20 EIA Interpretation: Negative: <20 units Weak Positive: 20 - 39 units Moderate Positive: 40 - 80 units Strong Positive: >80 units
Interpretive Data:
Anti-Jo 1 Abs are found in subset of myositis patients characterized by interstitial lung disease, systemic polyarthritis, Raynaud's Phenomena, fever and Mechanic's Hand (anti-synthetase syndrome).

Anti-Jo 1 appears to be a marker for interstitial lung disease in polymyositis.
Comments:
This mailout test requires pathologist approval for orders during inpatient encounters. Mailouts staff will not process order without approval. The pathologist covering mailouts approval can be reached at pager #5379. If approval is given, the name of the pathologist can be selected in the drop-down menu to the right of the approval warning in Epic when ordering the test.
Methodology:
RIPA and Enzyme Immunoassay (EIA)
CPT Code:
86235/Anti-Jo 1 Ab
83516/Mi-2
83516/PL-7
83516/PL-12
83516/EJ
83516/OJ
83516/Ku
83516/SRP
83516/U2 snRNP
83520/Anti-PM/Scl Ab