Beta D Glucan (Fungitell)
| Label Mnemonic: | BDGLUCAN |
| Epic code: | LAB2703 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Specimen
Instructions:
This test needs its own dedicated tube and cannot be shared with any
other tests.
Collection Medium:
) |
| BD Gold SST 5 mL Vacutainer |
Minimum:
Adult Absolute Minimum: 1 mL serum
Pediatric Absolute Minimum: 0.5 mL serum
Collection Instructions:
1. Avoid exposure of specimen to atmosphere.
2. Send specimen in original tube. Do not aliquot.
Pediatric Absolute Minimum: 0.5 mL serum
Collection Instructions:
1. Avoid exposure of specimen to atmosphere.
2. Send specimen in original tube. Do not aliquot.
Rejection Criteria:
Lipemic, icteric, or hemolyzed specimens. Specimens that have been
stored at ambient temperature. Specimens that have been stored at
2-8°C for >5 days. If storage longer than 5 days is needed,
samples should be frozen at -70°C. Unless indicated as stored
frozen, the specimen will be rejected if the draw date is >5 days from
receipt at reference laboratory.
Turn Around
Time:
24 hours upon receipt at reference laboratory (upon receipt in laboratory)
Reference Range:
Fungitell Quantitative Value:
<60 pg/mL
Fungitell Qualitative Results:
Negative
Reference values apply to all ages.
<60 pg/mL
Fungitell Qualitative Results:
Negative
Reference values apply to all ages.
Interpretive Data:
Glucan values of less than 60 pg/mL are interpreted as negative. Glucan
values of 60 to 79 pg/mL are interpreted as indeterminate, and suggest
a possible fungal infection. Additional sampling and testing of sera is
required to interpret the results.
Glucan values of greater than or equal to 80 pg/mL are interpreted as positive. Due to the potential for environmental contamination when transferred to pour-off tubes, which can lead to false positive results, interpret positive results from samples provided in pour-off tubes with caution. Results should be used in conjunction with clinical findings, and should not form the sole basis for a diagnosis or treatment decision. Fungitell is FDA approved or cleared for in vitro diagnostic use.
The Fungitell assay does not detect certain fungal species such as the genus Cryptococcus (Tanaka et. al. 1991) which produces very low levels of (1-3)-Beta-D-Glucan. The assay also does not detect the Zygomycetes such as Absidia, Mucor and Rhizopus (Mitsuya et al. 1994) which are not known to produce (1-3)-Beta-D-Glucan. In addition, the yeast phase of Blastomyces dermatitidis produces little (1-3)-Beta-D-Glucan and may not be detected by the assay (Girouard et al. 2007).
Glucan values of greater than or equal to 80 pg/mL are interpreted as positive. Due to the potential for environmental contamination when transferred to pour-off tubes, which can lead to false positive results, interpret positive results from samples provided in pour-off tubes with caution. Results should be used in conjunction with clinical findings, and should not form the sole basis for a diagnosis or treatment decision. Fungitell is FDA approved or cleared for in vitro diagnostic use.
The Fungitell assay does not detect certain fungal species such as the genus Cryptococcus (Tanaka et. al. 1991) which produces very low levels of (1-3)-Beta-D-Glucan. The assay also does not detect the Zygomycetes such as Absidia, Mucor and Rhizopus (Mitsuya et al. 1994) which are not known to produce (1-3)-Beta-D-Glucan. In addition, the yeast phase of Blastomyces dermatitidis produces little (1-3)-Beta-D-Glucan and may not be detected by the assay (Girouard et al. 2007).
Comments:
The Fungitell assay should be used in conjunction with other diagnostic procedures, such as routine bacterial/fungal cultures, histologic examination of biopsy material and radiologic studies.
Methodology:
Enzyme Immunoassay (EIA)
CPT Code:
87449