Coccidioides Antibody, CF/ID
Label Mnemonic: COCCI
Epic Lab Code: LAB2894
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Specimen Instructions:
Mark specimens plainly as "acute" or "convalescent."
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 2 mL serum
Absolute Minimum: 0.6 mL serum
Rejection Criteria:
Other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Turn Around Time:
2-5 days upon receipt at reference laboratory
Reference Range:
Component Name Reference Range Coccidioides Antibody by CF: < 1:2 Coccidioides Antibody by ID: None detected Coccidioides Antibody, IgG by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgG antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful 1.5 IV or greater = Positive Positive-Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection. Coccidioides Antibody, IgM by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgM antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.5 IV or greater = Positive Positive-Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
Interpretive Data:
Refer to individual components.

For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.
Methodology:
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi- Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code:
86635 Cocci Ab (CF)
86635 Cocci Ab (ID)
86635 Cocci Ab, IgG (EIA)
86635 Cocci Ab, IgM (EIA)