Levetiracetam (Keppra) Drug Level
Label Mnemonic: KEPPRA
Epic Lab Code: LAB477
Downtime Form: A-1a Therapeutic Drug Assay Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Whole Blood
Collection Medium:
Pink top tube 6 mL (K2-EDTA)
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
5 mL pink top tube (adults) or ONE EDTA Microtainer® devices (pediatric patients).
Rejection Criteria:
Gel separator tubes
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Therapeutic range: 5-30 μg/mL
Comments:
The proposed therapeutic range for seizure control is 5-30 μg/mL. Pharmacokinetics of levetiracetam are affected by renal function. The relationship between serum concentrations and toxicity is not known.
Test Limitations:
Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 1500 (approximate triglycerides concentration: 1500 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Methodology:
Enzyme Immunoassay
CPT Code:
80177