Zonisamide (Zonegran) Drug Level
Label Mnemonic: ZONI
Epic Lab Code: LAB504
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum or Plasma
Specimen Instructions:
Patient Preparation: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Separate serum from cells within 2 hours of collection.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum 1 mL serum
Absolute Minimum: 0.5 mL serum
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Turn Around Time:
4 days upon receipt at reference laboratory
Reference Range:
Therapeutic Range: Not well established.
Toxic Level: Greater than 80 μg/mL
Interpretive Data:
The proposed therapeutic range for seizure control is 10-40 μg/mL. Toxic concentrations may cause coma, seizures and cardiac abnormalities. Pharmacokinetics varies widely, particularly with co- medications and/or compromised renal function.
Test Limitations:
The proposed therapeutic range for seizure control is 10-40 μg/mL. Concentrations that exceed 80 μg/mL may contribute to adverse effects. Pharmacokinetics varies widely, particularly with co- medications and/or compromised renal function.
Methodology:
Quantitative Enzyme Multiplied Immunoassay Technique
CPT Code:
80203