Strongyloides Antibody, IgG by ELISA
Label Mnemonic: STRONGY
Epic Lab Code: LAB4099
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Collection Medium:
Red top tube 5 mL (Clot Activator)
Preferred Minimum: 1.0 mL serum in red top tube
Absolute Minimum: 0.3 mL serum in red top tube
Rejection Criteria:
Bacterially contaminated, heat-inactivated, hemolyzed, icteric, or lipemic specimens.
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
0.9 IV or less Negative - No significant level of Strongyloides IgG antibody detected. 1.0 IV Equivocal - The Strongyloides IgG antibody result is borderline and therefore inconclusive. Recommend retesting the patient in 2-4 weeks, if clinically indicated. 1.1 IV or greater Positive - IgG antibodies to Strongyloides detected, which may suggest current or past infection.
Interpretive Data:
False-positive results may occur with prior exposure to other helminth infections. Testing low-prevalence populations may also result in false-positive results.
Test Limitations:
This assay should be used to aid in the diagnosis and confirmation of patients in which there is a clinical suspicion of Strongyloides infection. Results for this test should not be used without correlation to clinical history or other data.

This assay will detect the presence of serum IgG antibodies against Strongyloides species. While diagnosis may be made clinically, serologic antibody testing can aid in the diagnosis of Strongyloidiasis. However, cutaneous larva migrans is observed with infections by other nematodes such as Ancylostoma species, Uncinaria stenocephala, and Bunostomum phlebotomum. Additionally, antibody cross-reactions in patients with filariasis may occur.

The enzyme immunoassay for Strongyloides antibody detection is recommended in place of IFA or IHA due to its sensitivity, which ranges from 84-92 percent. However, eight to 16 percent of individuals infected with Strongyloides are seronegative, so false-negative results cannot be ruled out. Additionally, since this assay measures Strongyloides-specific IgG in patient samples, test results from single samples cannot be used to differentiate between current and past infections.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code: