Endomysial IgG Antibody Screen with Reflex Titer and Interpretation
Label Mnemonic: EMAIGG
Epic Lab Code: LAB1305
Downtime Form: A-1a Immunopathology Requisition
Immunopathology
5238 RCP
356-2688
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Adult - 5 mL; red top tube
Pediatric - 2 mL; red top tube
Testing Schedule:
Bi-weekly (Mon and Thurs) - Batch analysis performed twice weekly on Mondays and Thursdays excluding university holidays.
Turn Around Time:
1 week
Reference Range:
< 1:5 Titer; Endomysial IgG antibody is useful in screening for celiac disease or dermatitis herpetiformis in patients with selective IgA deficiency. Selective IgA deficiency affects 3-5% of celiac and dermatitis herpetiformis patients. Endomysial IgG testing is not 100% sensitive for detection of such patients and it is recommended that anti-tissue transglutaminase EIA also be ordered for best sensitivity.

70-76% of patients with dermatitis herpetiformis and 90+% of patients with celiac disease who are on a gluten-containing diet. Occurrence of endomysial IgA antibody decreases significantly on gluten-free diets. Note: Selective IgA deficiencies affects 10-15% of celiac and DH patients and this condition will cause a false negative test. If IgA deficiency is known, please note on the requisition and IgG anti- EMA test will be done instead of IgA.
Comments:
Include relevant clinical information and consultation request.
Methodology:
Indirect Immunofluorescence
CPT Code:
86255 Endomysial Antibody IgG screen 86255-26 Endomysial Antibody IgG screen interpretation 86256 Endomysial Antibody IgG titer 86256-26 Endomysial Antibody IgG titer interpretation