UC-ANCA Screen and Interpretation
Label Mnemonic: UCANCAS
Epic Lab Code: LAB1365
Downtime Form: A-1a Immunopathology Requisition
Immunopathology
5238 RCP
356-2688
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Adult - 5 mL red top tube
Pediatric - 2 mL red top tube
Testing Schedule:
Daily - Batch analysis performed daily excluding weekends and university holidays.
Turn Around Time:
3 days
Reference Range:
<1:40 titer, includes interpretative report.
Comments:
"UC-ANCA" (also called "atypical P-ANCA" or "X-ANCA") is the type of ANCA most commonly found in some patients with certain inflammatory bowel and liver disease, namely, ulcerative colitis (72-80%), primary sclerosing cholangitis (72-80%), and autoimmune hepatitis type 1 (50-80%). A subset of patients with Crohn's Disease limited to the colon, may also be positive. Some patients with autoimmune connective tissues diseases (including systemic lupus erythematosus, rheumatoid arthritis and Felty's syndrome) may also have an autoantibody which produces the "atypical P-ANCA" pattern.

Since the specificity of this autoantibody has not yet been conclusively identified (and there may be more than one specificity), there is no confirmatory test. It is important to order this test only in the clinical setting of inflammatory bowel or liver disease. Note: Very rare patients with ulcerative colitis or primary sclerosing cholangitis may have one of the vasculitis-related ANCA specificities (anti-MPO or PR3).

Titration of "UC-ANCA" is not performed as studies have found no correlation between titer and disease activity.
Methodology:
Immunofluorescence
CPT Code:
86255 UC-ANCA Screen (Technical)
86255-26 UC-ANCA Screen (Professional Interpretation)