Varicella Zoster IgG Detection
Label Mnemonic: VZSC
Epic Lab Code: LAB2437
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
6240 RCP
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
3.0 mL whole blood from light green top tube or TWO Microtainer® devices.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
3 hours (upon receipt in laboratory)
Reference Range:
Reference range and methodology changed effective 12/11/2012.

0.8 AI or less: Negative - No significant level of detectable varicella- zoster IgG antibody.

0.9-1.0 AI: Equivocal - Repeat testing in 10-14 days may be helpful.

1.1 AI or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past exposure/immunization to varicella-zoster.
Interpretive Data:
The best evidence for current infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

Varicella-zoster IgG antibody can be formed following varicella-zoster infection or after varicella-zoster vaccination. A reactive result is consistent with immune status to varicella-zoster virus. Non-reactive and equivocal results flag as abnormal in Epic which indicates non- immune or equivocal immune status to varicella-zoster. A non-reactive result does NOT imply varicella-zoster infection. If ordered in workup of possible varicella-zoster infection, the IgG antibody results should be interpreted in conjunction with other laboratory tests, clinical history, and physical examination.
Test Limitations:
Patients with a current primary infection of varicella may not begin producing measurable concentrations of anti- varicella antibodies until several days after infection. An assay for the presence of IgM varicella antibodies may be helpful in diagnosing recent infection.

A positive test result in immunocompromised patients receiving prophylactic treatment with zoster immune serum globulin or zoster immune plasma may not be indicative of prior infection with VZV.
Multiplex Flow Immunoassay
CPT Code: