Varicella Zoster IgG Detection
| Label Mnemonic: | VZSC |
| Epic code: | LAB2437 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Chemistry
6240 RCP
356-3527
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
 |
| Plasma Separator Tube 4.5 mL |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3.0 mL whole blood from light green top tube or TWO Microtainer® devices.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
3 hours (upon receipt in laboratory)
Reference Range:
Reference range and methodology changed effective 12/11/2012.
0.8 AI or less: Negative - No significant level of detectable varicella- zoster IgG antibody.
0.9-1.0 AI: Equivocal - Repeat testing in 10-14 days may be helpful.
1.1 AI or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past exposure/immunization to varicella-zoster.
0.8 AI or less: Negative - No significant level of detectable varicella- zoster IgG antibody.
0.9-1.0 AI: Equivocal - Repeat testing in 10-14 days may be helpful.
1.1 AI or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past exposure/immunization to varicella-zoster.
Interpretive Data:
The best evidence for current infection is a significant change on two
appropriately timed specimens, where both tests are done in the same
laboratory at the same time.
Varicella-zoster IgG antibody can be formed following varicella-zoster infection or after varicella-zoster vaccination. A reactive result is consistent with immune status to varicella-zoster virus. Non-reactive and equivocal results flag as abnormal in Epic which indicates non- immune or equivocal immune status to varicella-zoster. A non-reactive result does NOT imply varicella-zoster infection. If ordered in workup of possible varicella-zoster infection, the IgG antibody results should be interpreted in conjunction with other laboratory tests, clinical history, and physical examination.
Varicella-zoster IgG antibody can be formed following varicella-zoster infection or after varicella-zoster vaccination. A reactive result is consistent with immune status to varicella-zoster virus. Non-reactive and equivocal results flag as abnormal in Epic which indicates non- immune or equivocal immune status to varicella-zoster. A non-reactive result does NOT imply varicella-zoster infection. If ordered in workup of possible varicella-zoster infection, the IgG antibody results should be interpreted in conjunction with other laboratory tests, clinical history, and physical examination.
Test
Limitations:
Patients with a current primary infection of varicella may not begin
producing measurable concentrations of anti- varicella antibodies until
several days after infection. An assay for the presence of IgM
varicella antibodies may be helpful in diagnosing recent
infection.
A positive test result in immunocompromised patients receiving prophylactic treatment with zoster immune serum globulin or zoster immune plasma may not be indicative of prior infection with VZV.
A positive test result in immunocompromised patients receiving prophylactic treatment with zoster immune serum globulin or zoster immune plasma may not be indicative of prior infection with VZV.
Methodology:
Multiplex Flow Immunoassay
CPT Code:
86787