Vancomycin Drug Level

Label Mnemonic:	VANC
Epic code:	LAB41
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Plasma

Collection Medium:

Plasma Separator Tube 4.5 mL

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3 mL whole blood in light green top tube or ONE Microtainer^®.

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

peak 30-40 μg/mL; (30-60 minutes after I.V. infusion)
trough  5-10 μg/mL; (not more than 30 minutes before next dose)

Critical value: >30 μg/mL

Comments:

Assay methodology updated to Roche Diagnostics Vancomycin III assay on 8/1/17. Critical value threshold changed on 12/5/17.

Test Limitations:

Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 1000 (approximate triglycerides concentration: 1000 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL).

No significant interference from total protein up to 12 g/dL or rheumatoid factors up to 1200 IU/mL.

As with any assay employing mouse antibodies, the possibility exists for interference by human anti-mouse antibodies (HAMA) in the sample, which could cause falsely lowered results.

Methodology:

Kinetic Interaction of Microparticles in Solution (KIMS)

CPT Code:

80202

See Additional Information:
Chemistry Critical Lab Values