Vancomycin
Label Mnemonic: VANC
Epic Lab Code: LAB41
Downtime Form: A-1a Therapeutic Drug Assay Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL whole blood in light green top tube or ONE Microtainer®.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
peak 30-40 μg/mL; (30-60 minutes after I.V. infusion) trough 5-10 μg/mL; (not more than 30 minutes before next dose) Critical value: >50 μg/mL
Comments:
Assay methodology updated to Roche Diagnostics Vancomycin III assay on 8/1/17.
Test Limitations:
Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 1000 (approximate triglycerides concentration: 1000 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL).

No significant interference from total protein up to 12 g/dL or rheumatoid factors up to 1200 IU/mL.

As with any assay employing mouse antibodies, the possibility exists for interference by human anti-mouse antibodies (HAMA) in the sample, which could cause falsely lowered results.
Methodology:
Kinetic Interaction of Microparticles in Solution (KIMS)
CPT Code:
80202
 
See Additional Information:
Chemistry Critical Lab Values