Uric Acid
Label Mnemonic: URIC
Epic Lab Code: LAB141
Downtime Form: A-1a General Laboratory Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL whole blood in light green top tube or ONE Microtainer® for pediatric patients.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
3.4-7.0 mg/dL (males) and 2.4-5.7 mg/dL (females) Pediatric Reference Ranges: Age Range Units 0-2 years 2.0-7.0 mg/dL 2-12 years 2.0-6.5 mg/dL 12-14 years 2.0-7.0 mg/dL
Comments:
Refer to BD Microtainer® Tubes product sheet for detailed sample collection instructions.

For patients who have received rasburicase (Elitek) within 48 hours of anticipated blood draw, "Uric Acid (on ice-Elitek)" (Epic #LAB870) should be ordered instead to avoid falsely low uric acid levels due to breakdown of uric acid by the uricase enzyme in the blood tube. See additional information listed in the links below.

This test is also performed in the Iowa River Landing (IRL) clinical laboratory (for specimens drawn at that site).
Test Limitations:
Criterion: Recovery within plus or minus 10% of initial values Plasma Icterus: No significant interference up to an I index of 40 (approximate conjugated and unconjugated bilirubin concentration 40 mg/dL or 684 umol/l). Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL or 621 umol/l). Lipemia (Intralipid): No significant interference up to an L index of 1500. There is poor correlation between turbidity and triglycerides concentration. Ascorbic acid less than 3 mg/dL does not interfere. Of the drugs tested in vitro, o-methyldopa, desferoxamine and calcium dobesilate (e.g. Dexium) cause interference at therapeutic concentrations (uric acid level artificially low). Uricase reacts specifically with uric acid. Other purine derivatives can inhibit the uric acid reaction. Reference: Glick MR, Ryder KW, Jackson SA. Graphical Comparisons of Interferences in Clinical Chemistry Instrumentation. Clin Chem 1986;32:470-474.
Methodology:
Enzymatic Colorimetric
CPT Code:
84550
 
See also:
Uric Acid (on ice-Elitek), Plasma
Uric Acid-Other, Body Fluid
 
See Additional Information:
Chemistry Pediatric Reference Ranges