Collect before next dose.
|Lavender top tube 3 mL (EDTA)
Call laboratory for additional acceptable specimen collection containers.
Preferred Minimum: 3 mL whole blood in lavender top tube (EDTA) or
ONE lavender top (EDTA) microtube for pediatric patients, mix well.
Results are available 1200 Monday-Sunday. Samples need to be in lab by
0900 for results at 1200 (daily).
24 hours (upon receipt in laboratory)
Therapeutic range 5.0 - 20.0 ng/mL
Analysis performed using the Abbott Diagnostics Tacrolimus immunoassay
on the Architect platform. The general therapeutic range for
tacrolimus is 5-20 ng/mL. The optimal therapeutic range for a given
patient may differ from this suggested range based on the indication
for therapy, treatment phase (initiation or maintenance), use in
combination with other drugs, time of specimen collection relative to
prior dose, type of transplanted organ, and/or the therapeutic
approach of the transplant center. Tacrolimus whole blood
concentrations can be measured by either immunoassay or
chromatographic methodologies. These two methodologies are not
directly interchangeable, and the measured tacrolimus whole blood
concentration depends on the methodology used. Reference ranges may
vary according to the specific immunoassay or HPLC-MS/MS test.
Generally, immunoassays have been reported to have a positive bias
relative to HPLC-MS/MS assays due to the detection of antibody cross-
reactivity with tacrolimus metabolites.
Chemiluminescent Microparticle Immunoassay