Glomerular Basement Membrane Antibodies, IgG
| Label Mnemonic: | GBM |
| Epic code: | LAB1255 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Chemistry
6240 RCP
356-3527
6240 RCP
356-3527
Specimen(s):
Serum
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Adult - 5 mL; red top tube Pediatric - 2 mL; red top tube
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
3 hours (upon receipt in laboratory)
Reference Range:
Negative: < 0.4 antibody index (AI)
Equivocal: 0.4-0.9
Positive: 1.0 AI or greater
Equivocal: 0.4-0.9
Positive: 1.0 AI or greater
Interpretive Data:
Glomerular basement membrane (GBM) antibodies are used for evaluating
with rapid onset renal failure or pulmonary hemorrhage and as an aid in
the diagnosis of Goodpasture syndrome in conjunction with clinical
history and physical examination. Positive results for GBM antibodies
are consistent with Goodpasture syndrome. GBM antibodies are highly
specific for Goodpasture syndrome. The sensitivity of this test is
approximately 87% in untreated patients with systemic disease.
Comments:
Assay methodology and reference ranges changed February 5, 2013.
References:
Pusey CD. Anti-glomerular basement membrane disease. Kidney Int 2003; 64:1535-1550.
References:
Pusey CD. Anti-glomerular basement membrane disease. Kidney Int 2003; 64:1535-1550.
Methodology:
Multiplex flow immunoassay
CPT Code:
83520