Glomerular Basement Membrane Antibodies, IgG
|Red top tube 5 mL (Clot Activator)
Adult - 5 mL; red top tube
Pediatric - 2 mL; red top tube
24 hrs/day, 7 days a week, including holidays.
3 hours (upon receipt in laboratory)
Negative: < 0.4 antibody index (AI)
Positive: 1.0 AI or greater
Glomerular basement membrane (GBM) antibodies are used for evaluating
with rapid onset renal failure or pulmonary hemorrhage and as an aid in
the diagnosis of Goodpasture syndrome in conjunction with clinical
history and physical examination. Positive results for GBM antibodies
are consistent with Goodpasture syndrome. GBM antibodies are highly
specific for Goodpasture syndrome. The sensitivity of this test is
approximately 87% in untreated patients with systemic disease.
Assay methodology and reference ranges changed February 5, 2013.
Pusey CD. Anti-glomerular basement membrane disease. Kidney Int 2003;
Multiplex flow immunoassay