Protein-Urine, Random

Label Mnemonic:	URPR
Epic code:	LAB845
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Urine, Random (Includes Prot/Creat Ratio)

Collection Medium:

Clear top tube

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3.0 mL random urine; no preservatives.

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

The reference range for the urine protein/creatinine ratio is < 0.2 for 2 years or older. Reference range for the ratio is not established for children less than 2 years old. No established reference range for random urine protein concentration.

Comments:

Creatinine performed on all urine protein orders, resulting 
additionally in a protein/creatinine ratio for all results.  The urine 
protein/creatinine ratio allows for an estimation of proteinuria based 
on a single random urine collection.  A 24 hour urine protein 
determination remains the recommended true measure of proteinuria.

References:
   Morgenstern BZ, Butini L, Wollan P, et al. Am J Kid Dis 2003
   Apr;41(4):760-766

   National Kidney Foundation: Am J Kid Dis 2002;39:S93-S102 (suppl1)

   Wilson DM, Anderson RL.  Am J Clin Pathol 1993;100:419-424

Test Limitations:

Contamination of urine with menstrual blood, prostatic 
secretions, or semen may result in increased urine protein levels.  
Vigorous exercise in healthy individuals may result in increased urine 
protein levels.  Intra individual variability in creatinine clearance 
can be due to diet (e.g., amount of ingested meat) and total skeletal 
muscle mass.

Criterion: recovery plus or minus 10% of initial values

Icterus: No significant interference up to an I index of 45 
(approximate conjugated and unconjugated bilirubin concentration: 45 
mg/dL).

Hemolysis: No significant interference up to an H index of 50.

No significant interference from:
Ascorbic Acid    Creatinine       Glucose
Phosphorus       Urea             Magnesium
Sodium Citrate   Caffeine         Cefazolin Sodium
Chlorpromazine   Calcium          L-Dopa Gentamicin
Sulfate          Sodium Oxalate   Uric Acid

Methodology:

Turbidimetric (protein)
Kinetic Colorimetric (creatinine)

CPT Code:

84156 (protein)
82570 (creatinine)

See Additional Information:
Urine Tests Requiring no Preservatives