Primidone And Metabolite Drug Level

Label Mnemonic:	PRIM
Epic code:	LAB485
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Plasma

Collection Medium:

Green top tube 4 mL (Na Heparin)

Minimum:

Preferred Minimum:  1 mL plasma
Absolute Minimum:  0.8 mL plasma

Rejection Criteria:

Separator tubes

Turn Around Time:

24 hours upon receipt at reference laboratory (upon receipt in laboratory)

Reference Range:

Phenobarbital      0-2 months: 15.0-30.0 μg/mL
                     Toxic: 40.1 μg/mL or greater
                   3 months and older: 15.0-40.0 μg/mL
                     Toxic: 50.1 μg/mL or greater

Primidone          5-12 μg/mL

Interpretive Data:

Primidone concentrations greater than 15 μg/mL in conjunction with therapeutic levels of phenobarbital may be associated with toxicity.

Methodology:

Immunoassay

CPT Code:

80188 Primidone; 80184 Phenobarbital