PM-Scl (PM1) Antibody, IgG
Label Mnemonic: PM100
Epic Lab Code: LAB7440
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 1 mL serum
Rejection Criteria:
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Turn Around Time:
1-4 days upon receipt at reference laboratory.
Reference Range:
Negative
Interpretive Data:
The presence of PM/Scl-100 IgG antibody along with a positive ANA IFA nucleolar pattern is associated with connective tissue diseases such as polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), and polymyositis/systemic sclerosis overlap syndrome. The clinical relevance of PM/Scl-100 IgG antibody with a negative ANA IFA nucleolar pattern is unknown. PM/Scl-100 is the main target epitope of the PM/Scl complex, although antibodies to other targets not detected by this assay may occur.
Methodology:
Qualitative Immunoblot
CPT Code:
86235