Insulin Like Growth Factor Binding Protein III (IGFBP-3)
Label Mnemonic: IGFB3
Epic Lab Code: LAB3408
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 0.5 mL serum from red top tube
Rejection Criteria:
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Turn Around Time:
1-2 days upon receipt at reference laboratory.
Reference Range:
Age Male Female 0-12 months 1039-3169 ng/mL 1039-3169 ng/mL 1-3 years 972-4123 ng/mL 1590-4225 ng/mL 4-5 years 1843-4968 ng/mL 2169-4790 ng/mL 6-7 years 1838-4968 ng/mL 2188-4996 ng/mL 8-9 years 1932-5858 ng/mL 2072-5504 ng/mL 10-11 years 1828-6592 ng/mL 2456-6992 ng/mL 12-13 years 2134-6598 ng/mL 2838-6846 ng/mL 14-15 years 2330-6550 ng/mL 2654-6680 ng/mL 16-17 years 2380-6400 ng/mL 2756-6908 ng/mL 18-19 years 2340-6632 ng/mL 2700-6492 ng/mL 20-24 years 2404-5948 ng/mL 3032-5992 ng/mL 25-29 years 2614-5792 ng/mL 2926-5858 ng/mL 30-34 years 2500-5806 ng/mL 2878-6650 ng/mL 35-39 years 2474-5208 ng/mL 2786-6084 ng/mL 40-44 years 2360-5560 ng/mL 2514-6014 ng/mL 45-49 years 2314-5700 ng/mL 2838-4954 ng/mL 50-54 years 2528-5050 ng/mL 2562-5596 ng/mL 55-59 years 2482-5460 ng/mL 2574-5914 ng/mL 60-64 years 2592-4770 ng/mL 2684-5130 ng/mL 65 years and older 2698-5688 ng/mL 2462-5274 ng/mL Tanner Stage I 1878-6190 ng/mL 2314-6086 ng/mL Tanner Stage II 2112-6208 ng/mL 2732-6738 ng/mL Tanner Stage III 2372-6602 ng/mL 2870-7068 ng/mL Tanner Stage IV & V 2336-6414 ng/mL 2756-7232 ng/mL
Comments:
Insulin-like growth factor binding proteins binds IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of the circulating IGF-I and IGF-II.

IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH- deficient children after GH administration.

Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay can be useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.
Methodology:
Quantitative Chemiluminescent Immunoassay
CPT Code:
82397