Insulin Like Growth Factor Binding Protein III (IGFBP-3)
Label Mnemonic: IGFB3
Epic code: LAB3408
Downtime form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 0.5 mL serum from red top tube
Rejection Criteria:
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Turn Around Time:
1-2 days upon receipt at reference laboratory.
Reference Range:
Age                     Male                Female
0-12 months             1039-3169 ng/mL     1039-3169 ng/mL
1-3 years               972-4123 ng/mL      1590-4225 ng/mL
4-5 years               1843-4968 ng/mL     2169-4790 ng/mL
6-7 years               1838-4968 ng/mL     2188-4996 ng/mL
8-9 years               1932-5858 ng/mL     2072-5504 ng/mL
10-11 years             1828-6592 ng/mL     2456-6992 ng/mL
12-13 years             2134-6598 ng/mL     2838-6846 ng/mL
14-15 years             2330-6550 ng/mL     2654-6680 ng/mL
16-17 years             2380-6400 ng/mL     2756-6908 ng/mL
18-19 years             2340-6632 ng/mL     2700-6492 ng/mL
20-24 years             2404-5948 ng/mL     3032-5992 ng/mL
25-29 years             2614-5792 ng/mL     2926-5858 ng/mL
30-34 years             2500-5806 ng/mL     2878-6650 ng/mL
35-39 years             2474-5208 ng/mL     2786-6084 ng/mL
40-44 years             2360-5560 ng/mL     2514-6014 ng/mL
45-49 years             2314-5700 ng/mL     2838-4954 ng/mL
50-54 years             2528-5050 ng/mL     2562-5596 ng/mL
55-59 years             2482-5460 ng/mL     2574-5914 ng/mL
60-64 years             2592-4770 ng/mL     2684-5130 ng/mL
65 years and older      2698-5688 ng/mL     2462-5274 ng/mL
Tanner Stage I          1878-6190 ng/mL     2314-6086 ng/mL
Tanner Stage II         2112-6208 ng/mL     2732-6738 ng/mL
Tanner Stage III        2372-6602 ng/mL     2870-7068 ng/mL
Tanner Stage IV & V     2336-6414 ng/mL     2756-7232 ng/mL
Comments:
Insulin-like growth factor binding proteins binds IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of the circulating IGF-I and IGF-II.

IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH- deficient children after GH administration.

Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay can be useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.
Methodology:
Quantitative Chemiluminescent Immunoassay
CPT Code:
82397