Alkaline Phosphatase Isoenzyme

Label Mnemonic:	ALPI
Epic code:	LAB2552
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Specimen Instructions:

Patient's age and sex are required.

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

1 mL of serum divided into TWO tubes each containing 0.5 mL

Testing Schedule:

Alkaline Phosphatase: Monday through Sunday; Continuously
Alkaline Phosphatase Isoenzymes: Monday through Friday

Turn Around Time:

2 days upon receipt at reference laboratory

Reference Range:

ALKALINE PHOSPHATASE
        Males                        Females
 4 years: 149-369 U/L          4 years: 169-372 U/L
 5 years: 179-416 U/L          5 years: 162-355 U/L
 6 years: 179-417 U/L          6 years: 169-370 U/L
 7 years: 172-405 U/L          7 years: 183-402 U/L
 8 years: 169-401 U/L          8 years: 199-440 U/L
 9 years: 175-411 U/L          9 years: 212-468 U/L
10 years: 191-435 U/L         10 years: 215-476 U/L
11 years: 185-507 U/L         11 years: 178-526 U/L
12 years: 185-562 U/L         12 years: 133-485 U/L
13 years: 182-587 U/L         13 years: 120-449 U/L
14 years: 166-571 U/L         14 years: 153-362 U/L
15 years: 138-511 U/L         15 years: 75-274 U/L
16 years: 102-417 U/L         16 years: 61-264 U/L
17 years: 69-311 U/L          17-23 years: 52-144 U/L
18 years: 52-222 U/L          24-45 years: 37-98 U/L
> or =19 years: 45-115 U/L    46-50 years: 39-100 U/L
                              51-55 years: 41-108 U/L
                              56-60 years: 46-118 U/L
                              61-65 years: 50-130 U/L
                              > or =66 years: 55-142 U/L
Reference values have not been established for patients that are <4 
years of age.

ALKALINE PHOSPHATASE ISOENZYMES
       Liver 1%                       Liver 1
0-6 years: 5.1-49.0%           0-6 years: 7.0-112.7 IU/L
7-9 years: 3.0-45.0%           7-9 years: 7.4-109.1 IU/L
10-13 years: 2.9-46.3%        10-13 years: 7.8-87.6 IU/L
14-15 years: 7.8-48.9%        14-15 years: 10.3-75.6 IU/L
16-18 years: 14.9-50.5%       16-18 years: 13.7-78.5 IU/L
> or =19 years: 27.8-76.3%    > or =19 years: 16.2-70.2 IU/L

       Liver 2%                        Liver 2
0-6 years: 2.9-13.7%           0-6 years: 3.0-41.5 IU/L
7-9 years: 3.7-12.5%           7-9 years: 4.0-35.6 IU/L
10-13 years: 2.9-22.3%        10-13 years: 3.3-37.8 IU/L
14-15 years: 2.2-19.8%        14-15 years: 2.2-32.1 IU/L
16-18 years: 1.9-12.5%        16-18 years: 1.4-19.7 IU/L
> or =19 years: 0.0-8.0%      > or =19 years: 0.0-5.8 IU/L

       Bone %                          Bone
0-6 years: 41.5-82.7%          0-6 years: 43.5-208.1 IU/L
7-9 years: 39.9-85.8%          7-9 years: 41.0-258.3 IU/L
10-13 years: 31.8-91.1%       10-13 years: 39.4-346.1 IU/L
14-15 years: 30.6-85.4%       14-15 years: 36.4-320.5 IU/L
16-18 years: 38.9-72.6%       16-18 years: 32.7-214.6 IU/L
> or =19 years: 19.1-67.7%    > or =19 years: 12.1-42.7 IU/L

     Intestine %                    Intestine
0-6 years: 0.0-18.4%           0-6 years: 0.0-37.7 IU/L
7-9 years: 0.0-18.3%           7-9 years: 0.0-45.6 IU/L
10-13 years: 0.0-11.8%        10-13 years: 0.0-40.0 IU/L
14-15 years: 0.0-8.2%         14-15 years: 0.0-26.4 IU/L
16-18 years: 0.0-8.7%         16-18 years: 0.0-12.7 IU/L
> or =19 years: 0.0-20.6%     > or =19 years: 0.0-11.0 IU/L

Placental
Not present

Comments:

Useful for:
  Diagnosis and treatment of liver, bone, intestinal, and parathyroid
  diseases

  Determining the tissue source of increased alkaline phosphatase (ALP)
  activity in serum

  Differentiating between liver and bone sources of elevated ALP

Test Limitations:

Bone Specific Alkaline Phosphatase and 5'nucleotidase may be useful in identifying disorders of bone and liver, respectively.

Methodology:

ALP: Photometric, p-Nitrophenol Phosphate
ALKE: Electrophoresis

CPT Code:

84075, 84080