Topiramate (Topir) Drug Level
Label Mnemonic: TOPR
Epic Lab Code: LAB498
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Specimen Instructions:
Timing of specimen collection: Pre-dose (trough) draw At steady state concentration.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 1.0 mL serum
Absolute Minimum: 0.3 mL serum
Rejection Criteria:
Gel separator tubes
Delivery Instructions:
Deliver to laboratory immediately after collection.
Turn Around Time:
Within 24 hours upon receipt at reference laboratory.
Reference Range:
Therapeutic range: 5.0-20.0 μg/mL Toxic: not well established
Interpretive Data:
The proposed therapeutic range for seizure control is 5-20 μg/mL. Pharmacokinetics varies widely, particularly with co-medications, age, and/or compromised renal function.
Methodology:
Quantitative Enzyme Immunoassay
CPT Code:
80339