|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Red top tube 5 mL (Clot Activator)|
Pediatric - 2 mL; red top tube
Equivocal: 0.4-0.9 AI
Positive: 1.0 AI or greater
Autoantibodies to MPO occur in several diseases and may be involved in the pathogenesis of MPA. MPO autoantibodies are not specific for MPA and may also be detected in patients with Goodpasture syndrome, systemic necrotizing glomerulonephritis, and Churg-Strauss syndrome.
Titers to MPO antibodies may be useful to follow treatment response.
Russel KA et al. Detection of anti-neutrophil cytoplasmic antibodies under actual clinical testing conditions. Clin Immunol 2002; 103:196- 203.