Mercury
Label Mnemonic: HGU
Epic Lab Code: LAB408
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Specimen Instructions:
Refrigerate during collection in plastic container. Studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non- essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.
Collection Medium:
Urine - 24 hour/timed plastic urine container
Minimum:
Preferred Minimum: 8 mL aliquot from a well-mixed collection from 24 hour collection.

Absolute Minimum: 1 mL aliquot from a well-mixed collection from 24 hour collection.

Refrigerate during collection and submission.
Rejection Criteria:
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine. Specimens contaminated with blood or fecal material. Specimens transported in non-trace element free transport tube (with the exception of the original device).
Turn Around Time:
4 days upon receipt at reference laboratory
Reference Range:
COMPONENTS REFERENCE INTERVAL Mercury, Urine-per 24h 0.0-2.9 μg/L Mercury, Urine-per volume 0.0-1.9 μg/d Mercury, Urine-ratio to CRT 0.0-20.0 μg/gCRT Creatinine, Urine-per 24h mg/d Male Female 3-8 yrs: 140-700 3-8 yrs: 140-700 9-12 yrs: 300-1300 9-12 yrs: 300-1300 13-17 yrs: 500-2300 13-17 yrs: 400-1600 18-50 yrs: 1000-2500 18-50 yrs: 700-1600 51-80 yrs: 800-2100 51-80 yrs: 500-1400 81 yrs+: 600-2000 81 yrs+: 400-1300
Interpretive Data:
Urinary mercury levels predominantly reflect acute or chronic elemental or inorganic mercury exposure. Urine concentrations in unexposed individuals are typically less than 10 g/L. 24 hour urine concentrations of 30 to 100 g/L may be associated with subclinical neuropsychiatric symptoms and tremor while concentrations greater than 100 g/L can be associated with overt neuropsychiatric disturbances and tremors. Urine mercury levels may be useful in monitoring chelation therapy.
Comments:
Record total volume and collection time interval on transport tube and on test request form.

Stability: Mercury is volatile; concentration may reduce after seven days or more storage.
Methodology:
Quantitative Inductively Coupled Plasma-Mass Spectrometry
CPT Code:
83825