Amiodarone & Metabolite Drug Level
Commercial Mail-out Laboratory
Timing of specimen collection: Pre-dose (trough) draw - at steady
|Red top tube 5 mL (Clot Activator)
Preferred Minimum: 1 mL serum
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS
or ACD solution).
1-4 days upon receipt at reference laboratory
Therapeutic Range: 0.5-2.0 μg/mL
Toxic Level: Greater than 3.0 μg/mL
Toxic concentrations may exacerbate arrhythmias, cause liver and lung
toxicity, and thyroid dysfunction. The concentration of
desethylamiodarone, an active major metabolite, is also reported but
no therapeutic range is established. At steady-state, the metabolite
concentration is similar to the amiodarone concentration.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry