Amiodarone & Metabolite Drug Level
Label Mnemonic: AMIO
Epic code: LAB2580
Downtime form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
Specimen Instructions:
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Preferred Minimum: 1 mL serum
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Testing Schedule:
Monday-Tuesday, Thursday-Saturday
Turn Around Time:
1-4 days upon receipt at reference laboratory
Reference Range:
Therapeutic Range: 0.5-2.0 μg/mL
Toxic Level: Greater than 3.0 μg/mL
Interpretive Data:
Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code: