Lead
Label Mnemonic: UPB
Epic code: LAB404
Downtime form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
356-8593
Specimen(s):
Specimen Instructions:
Refrigerate during 24 hr collection in plastic container. Reference laboratory studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non- essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Collection of urine specimens from patients receiving iodinated or gadolinium-based contrast media should be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post-contrast media exposure.
Collection Medium:
Urine - 24 hour/timed plastic urine container
Minimum:
Preferred Minimum: 8 mL aliquot from 24 hour collection.
Absolute Minimum: 1 mL aliquot from 24 hour collection.

Refrigerate during collection and submission.
Rejection Criteria:
Urine collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens contaminated with blood or fecal material. Specimens transported in non-trace element free transport tube (with the exception of the original device).
Turn Around Time:
1-5 days upon receipt at reference laboratory
Reference Range:
COMPONENTS                     REFERENCE INTERVAL
Lead, Urine - per Volume       0.0 - 5.0 μg/d
Lead, Urine - per 24 hour      0.0 - 8.1 μg/L
Lead Urine - ratio to CRT      0.0 - 5.0 μg/gCRT

Creatinine, Urine-per 24 hr (mg/d)    Male                 Female
                               3-8 yrs: 140-700      3-8 yrs: 140-700
                               9-12 yrs: 300-1300    9-12 yrs: 300-1300
                              13-17 yrs: 500-2300   13-17 yrs: 400-1600
                              18-50 yrs: 1000-2500  18-50 yrs: 700-1600
                              51-80 yrs: 800-2100   51-80 yrs: 500-1400
                              81 yrs+: 600-2000     81 yrs+: 400-1300 
Interpretive Data:
Quantification of urine excretion rates before or after chelation therapy has been used as an indicator of lead exposure. Urinary excretion of >125 mg of lead per 24 hours is usually associated with related evidence of lead toxicity.
Methodology:
Quantitative Inductively Coupled Plasma/Mass Spectrometry
CPT Code:
83655