Lead
Label Mnemonic: UPB
Epic Lab Code: LAB404
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Specimen Instructions:
Refrigerate during 24 hr collection in plastic container. Reference laboratory studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non- essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.
Collection Medium:
Urine - 24 hour/timed plastic urine container
Minimum:
Preferred Minimum: 8 mL aliquot from 24 hour collection.
Absolute Minimum: 1 mL aliquot from 24 hour collection.

Refrigerate during collection and submission.
Rejection Criteria:
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine.
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
COMPONENTS REFERENCE INTERVAL Lead, Urine - per 24 hour 0.0 - 8.1 μg/L Lead, Urine - per volume 0.0 - 1.4 μg/d Lead Urine - ratio to CRT 0.0 - 1.4 μg/gCRT Creatinine, Urine-per 24 hr (mg/d) Male Female 3-8 yrs: 140-700 3-8 yrs: 140-700 9-12 yrs: 300-1300 9-12 yrs: 300-1300 13-17 yrs: 500-2300 13-17 yrs: 400-1600 18-50 yrs: 1000-2500 18-50 yrs: 700-1600 51-80 yrs: 800-2100 51-80 yrs: 500-1400 81 yrs+: 600-2000 81 yrs+: 400-1300
Interpretive Data:
Quantification of urine excretion rates before or after chelation therapy has been used as an indicator of lead exposure. Urinary excretion of >125 mg of lead per 24 hours is usually associated with related evidence of lead toxicity.
Methodology:
Quantitative Inductively Coupled Plasma/Mass Spectrometry
CPT Code:
83655