Islet Cell Antibody, IgG

Label Mnemonic:	ISLET
Epic code:	LAB3446
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Recommended Minimum: 1 mL serum from red top tube
Absolute Minimum: 0.15 mL serum from red top tube

Rejection Criteria:

Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Turn Around Time:

3 days upon receipt at reference laboratory

Reference Range:

< 1:4 No antibody detected

Interpretive Data:

Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. These antibodies may be present in individuals years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5 = 40 JDF Units).

Test Limitations:

Islet cell antibodies have been associated with "autoimmune" 
endocrine disorders and insulin-dependent diabetes.  This disorder is 
characterized by the presence of antibodies in patients that may be 
detected years before the onset of the clinical symptoms.
To calculate Juvenile Diabetes Foundation (JDF) units:  Multiple the 
titer x 5.
  EXAMPLE:  1:8   8 x 5 = 40 JDF Units

Methodology:

Semi-Quantitative Indirect Fluorescent Antibody

CPT Code:

86341