|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Red top tube 5 mL (Clot Activator)|
Absolute Minimum: 0.25 mL serum
MYCOPHENOLIC ACID 1.0-3.5 mcg/mL MPA GLUCURONIDE 35-100 mcg/mL
Trough steady-state serum MPA levels >4.0 ug/mL indicate that the patient is overimmunosuppressed and susceptible to systemic infections. Decreased dosages may be indicated in these cases.
Monitoring is recommended immediately after transplant up to 3 weeks after therapy is initiated to evaluate dosing adequacy. Additional monitoring is indicated if the MPA level is not in the therapeutic range or if a major change in health status occurs.
Correct interpretation requires a trough serum specimen (just before the next regular dose). Specimens drawn at other times in the dosing cycle are likely to have higher MPA levels. In these cases, the reference range does not apply.