Histone Antibody, IgG

Label Mnemonic:	HIST
Epic code:	LAB3325
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.3 mL serum

Rejection Criteria:

Plasma or urine. Contaminated specimens. Grossly hemolyzed, lipemic, or icteric specimens.

Turn Around Time:

3 working days upon receipt at reference laboratory

Reference Range:

0.9 units or less       Negative 
1.0-1.5 units           Weak Positive 
1.6-2.5 units           Moderate Positive 
2.6 units or greater    Strong Positive

Test Limitations:

Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissues diseases.

Methodology:

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

CPT Code:

83516