Chromogenic Factor VIII Inhibitor
| Label Mnemonic: | CH8IN |
| Epic code: | LAB9508 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Hemostasis/Thrombosis
6240 RCP
356-3573
6240 RCP
356-3573
Specimen(s):
Plasma
Collection Medium:
 | and | |
| Light Blue top tube 2.7 mL (Na Citrate) | Light Blue top tube 2.7 mL (Na Citrate) |
Minimum:
Collect TWO Full tubes - 2.7 mL light blue top
Rejection Criteria: Short drawn tube, clot, traumatic tap (excessive hemolysis).
Delivery Instructions:
Deliver to laboratory immediately after collection.Turn Around
Time:
24-48 hours
Reference Range:
<0.5 BU
Methodology:
Chromogenic Bethesda Titer
CPT Code:
85335
See Additional Information:
Impact of Common Anticoagulants on Coagulation Tests
Impact of Common Anticoagulants on Coagulation Tests
The chromogenic factor VIII inhibitor must be ordered with a chromogenic factor VIII activity assay. The inhibitor will not be performed if the activity assay is ≥ 25%. The chromogenic factor VIII inhibitor assay utilizes bovine factor X and human thrombin and factor IXa. It is insensitive to emicizumab, but may yield unreliable results in the presence of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban), high concentrations of heparin (>2 IU/mL), strong lupus anticoagulants (ratio >1.8), or the Mim8 bispecific antibody.