Publications 1996-1999: Links take you to the PubMed listing where many papers can be downloaded free.
1: | Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. | |
Novel mechanism of hypertension revealed by cell-specific
targeting of human angiotensinogen in transgenic mice. Physiol Genomics. 1999 Jul 15;1(1):3-9. |
2: | Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD, Haynes WG. | |
Contrasting blood pressure effects of obesity in
leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens. 1999 Dec;17(12 Pt 2):1949-53. |
3: | Faraci FM, Sigmund CD. | |
Vascular biology in genetically altered mice : smaller
vessels, bigger insight. Circ Res. 1999 Dec 3-17;85(12):1214-25. Review. |
4: | Sinn PL, Davis DR, Sigmund CD. | |
Highly regulated cell type-restricted expression of human
renin in mice containing 140- or 160-kilobase pair P1 phage artificial
chromosome transgenes. J Biol Chem. 1999 Dec 10;274(50):35785-93. |
5: | Sinn PL, Zhang X, Sigmund CD. | |
JG cell expression and partial regulation of a human renin
genomic transgene driven by a minimal renin promoter. Am J Physiol. 1999 Oct;277(4 Pt 2):F634-42. |
6: | Shi Q, Black TA, Gross KW, Sigmund CD. | |
Species-specific differences in positive and negative
regulatory elements in the renin gene enhancer. Circ Res. 1999 Sep 17;85(6):479-88. |
7: | Lake-Bruse KD, Faraci FM, Shesely EG, Maeda N, Sigmund CD, Heistad DD. | |
Gene transfer of endothelial nitric oxide synthase (eNOS)
in eNOS-deficient mice. Am J Physiol. 1999 Aug;277(2 Pt 2):H770-6. |
8: | Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD. | |
Efficient liver-specific deletion of a floxed human
angiotensinogen transgene by adenoviral delivery of Cre recombinase in
vivo. J Biol Chem. 1999 Jul 23;274(30):21285-90. |
9: | Sinn PL, Sigmund CD. | |
Human renin mRNA stability is increased in response to
cAMP in Calu-6 cells. Hypertension. 1999 Mar;33(3):900-5. |
10: | Yang G, Gray TS, Sigmund CD, Cassell MD. | |
The angiotensinogen gene is expressed in both astrocytes
and neurons in murine central nervous system. Brain Res. 1999 Jan 30;817(1-2):123-31. |
11: | Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF. | |
Kidney is the only source of human plasma renin in 45-kb
human renin transgenic mice. Circ Res. 1998 Dec 14-28;83(12):1279-88. |
12: | Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD. | |
The brain renin-angiotensin system contributes to the
hypertension in mice containing both the human renin and human
angiotensinogen transgenes. Circ Res. 1998 Nov 16;83(10):1047-58. |
13: | Stec DE, Sigmund CD. | |
Modifiable gene expression in mice: kidney-specific
deletion of a target gene via the cre-loxP system. Exp Nephrol. 1998 Nov-Dec;6(6):568-75. Review. |
14: | Yang G, Sigmund CD. | |
Developmental expression of human angiotensinogen in
transgenic mice. Am J Physiol. 1998 May;274(5 Pt 2):F932-9. |
15: | Yang G, Sigmund CD. | |
Regulatory elements required for human angiotensinogen
expression in HepG2 cells are dispensable in transgenic mice. Hypertension. 1998 Mar;31(3):734-40. |
16: | Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD. | |
Responses of carotid artery in mice deficient in
expression of the gene for endothelial NO synthase. Am J Physiol. 1998 Feb;274(2 Pt 2):H564-70. |
17: | Merrill DC, Granwehr BP, Davis DR, Sigmund CD. | |
Use of transgenic and gene-targeted mice to
model the genetic basis of hypertensive disorders. Proc Assoc Am Physicians. 1997 Nov;109(6):533-46. Review. |
18: | Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. | |
The kidney androgen-regulated protein promoter confers
renal proximal tubule cell-specific and highly androgen-responsive
expression on the human angiotensinogen gene in transgenic mice. J Biol Chem. 1997 Oct 31;272(44):28142-8. |
19: | Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF. | |
Conserved enhancer elements in human and mouse renin genes
have different transcriptional effects in As4.1 cells. Circ Res. 1997 Oct;81(4):558-66. |
20: | Petrovic N, Kane CM, Sigmund CD, Gross KW. | |
Downregulation of renin gene expression by interleukin-1. Hypertension. 1997 Aug;30(2 Pt 1):230-5. |
21: | Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD. | |
Complementation of reduced survival, hypotension, and
renal abnormalities in angiotensinogen-deficient mice by the human renin
and human angiotensinogen genes. J Clin Invest. 1997 Mar 15;99(6):1258-64. |
22: | Ying L, Morris BJ, Sigmund CD. | |
Transactivation of the human renin promoter by the cyclic
AMP/protein kinase A pathway is mediated by both cAMP-responsive element
binding protein-1 (CREB)-dependent and CREB-independent mechanisms in
Calu-6 cells. J Biol Chem. 1997 Jan 24;272(4):2412-20. |
23: | Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, Gross KW. | |
Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem. 1997 Jan 15;243(1-2):181-90. |
24: | Davisson RL, Sigmund CD. | |
Transgenic animal models as tools for studying renal
developmental physiology. Pediatr Nephrol. 1996 Dec;10(6):798-803. Review. |
25: | Davisson RL, Nuutinen N, Coleman ST, Sigmund CD. | |
Inappropriate splicing of a chimeric gene containing a
large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res. 1996 Oct 15;24(20):4023-8. |
26: | Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. | |
Role of proximal promoter elements in regulation of renin
gene transcription. J Biol Chem. 1996 Sep 13;271(37):22499-505. |
27: | Thompson MW, Smith SB, Sigmund CD. | |
Regulation of human renin mRNA expression and protein
release in transgenic mice. Hypertension. 1996 Aug;28(2):290-6. |
28: | Lang JA, Ying LH, Morris BJ, Sigmund CD. | |
Transcriptional and posttranscriptional mechanisms
regulate human renin gene expression in Calu-6 cells. Am J Physiol. 1996 Jul;271(1 Pt 2):F94-100. |
29: | Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. | |
Chronic hypertension and altered baroreflex responses in
transgenic mice containing the human renin and human angiotensinogen
genes. J Clin Invest. 1996 Feb 15;97(4):1047-55. |