Henry L. Keen, Ph.D.
Assistant Research Scientist
RESEARCH INTERESTS
Bioinformatics, biological databases, DNA microarrays, development of computational tools for genome analysis, computer simulation of physiological systems, gene-targeted mouse models of human disease.
Publications from Sigmund lab.
Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD.
J Biol Chem. 2010 Mar 26;285(13):9311-6. Epub 2010 Feb 3.
PMID: 20129921
Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD.
Arterioscler Thromb Vasc Biol. 2009 Dec 17. [Epub ahead of print]
PMID: 20018933
Regulation of renin gene expression by oxidative stress.
Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD.
Hypertension. 2009;53:1070-1076.
PMID: 19433777
Endothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet.
Circ Res. 2008;103:654-661.
PMID: 18676352
Dysregulated Human Renin Expression in Transgenic Mice Carrying Truncated Genomic Constructs: Evidence Supporting the Presence of Insulators at the Renin Locus.
Am J Physiol Renal Physiol. 2008;295:F642-653.
PMID: 18632798 [PubMed - as supplied by publisher]
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.
Cell Metab. 2008 Mar;7(3):215-26.
PMID: 18316027 [PubMed - indexed for MEDLINE]
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.
Hypertension. 2008 Apr;51(4):867-71. Epub 2008 Feb 19. Erratum in: Hypertension. 2008 Apr;51(4):e33.
PMID: 18285614 [PubMed - indexed for MEDLINE]
Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?
Hypertension. 2007 Nov;50(5):844-6. Epub 2007 Sep 4. No abstract available.
PMID: 17785627 [PubMed - indexed for MEDLINE]
Transgenic mice for studies of the renin-angiotensin system in hypertension.
Acta Physiol Scand. 2004 Aug;181(4):571-7. Review.
PMID: 15283772 [PubMed - indexed for MEDLINE]
Gene expression profiling of potential PPARgamma target genes in mouse aorta.
Physiol Genomics. 2004 Jun 17;18(1):33-42.
PMID: 15054141 [PubMed - indexed for MEDLINE]
Untraditional methods for targeting the kidney in transgenic mice.
Am J Physiol Renal Physiol. 2003 Dec;285(6):F1027-33. Review.
PMID: 14600026 [PubMed - indexed for MEDLINE]
Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.
Physiol Genomics. 2002 Dec 3;11(3):253-62.
PMID: 12388794 [PubMed - indexed for MEDLINE]
Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase.
Hypertension. 2002 Feb;39(2 Pt 2):629-33.
PMID: 11882621 [PubMed - indexed for MEDLINE]
Paradoxical regulation of short promoter human renin transgene by angiotensin ii.
Hypertension. 2001 Feb;37(2 Part 2):403-7.
PMID: 11230308 [PubMed - indexed for MEDLINE]
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