Debbie Davis, Research Assistant

I moved to the Sigmund Lab in July of 1997 after working in the Animal Care Unit for 5 years. I have a business degree from the University of Northern Iowa in Human Resource Management. I was hired to manage the animal portion of the lab and all aspects of physiology. I spend my time training and assisting the students in any area needed in regards to the mice. We perform various surgeries on mice, monitor blood pressure, collect blood, urine and measure food and water intake. I also am responsible for all the breeding of the many strains of mice we need generated. This involves weaning, ear clipping for identification and tail snipping for DNA results. I love working with the animal and the helping the students to achieve their goals here in the Sigmund Lab.

My free time is mostly spent with my soon to be 1 year old daughter Ellie. We like to go for walks and will soon begin a mommy and baby swim class. I love the water and spend a lot of my time in the summer at my dad's pool as my vacations to the Caribbean have been cut to a minimum with my new daughter!

Upstream Stimulatory Factor Is Required for Human Angiotensinogen Expression and Differential Regulation by the A-20C Polymorphism.

Circulation Research. 2008; 103: 940-947.

PMID: 18802024 [PubMed - as supplied by publisher]

 

2: Li H, Zhou X, Davis DR, Xu D, Sigmund CD.

An Androgen-Inducible Proximal Tubule-Specific Cre-Recombinase Transgenic Model.

Am J Physiol Renal Physiol. 2008, 294:F1481-F1486.

PMID: 18385272 [PubMed - as supplied by publisher]

 

3: Zhou X, Davis DR, Sigmund CD.

The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression.

J Biol Chem. 2006 Nov 17;281(46):35296-304. Epub 2006 Sep 21.

PMID: 16990260 [PubMed - indexed for MEDLINE]

 

4: Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD.

Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice.

Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1763-9. Epub 2005 Aug 18.

PMID: 16109805 [PubMed - indexed for MEDLINE]

 

5: Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD.

Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

Physiol Genomics. 2002 Dec 3;11(3):253-62.

PMID: 12388794 [PubMed - indexed for MEDLINE]

 

6: Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD.

Endothelial dysfunction and blood pressure variability in selected inbred mouse strains.

Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):42-8.

PMID: 11788459 [PubMed - indexed for MEDLINE]

 

7: Sinn PL, Davis DR, Sigmund CD.

Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes.

J Biol Chem. 1999 Dec 10;274(50):35785-93.

PMID: 10585461 [PubMed - indexed for MEDLINE]

 

8: Merrill DC, Granwehr BP, Davis DR, Sigmund CD.

Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders.

Proc Assoc Am Physicians. 1997 Nov;109(6):533-46. Review.

PMID: 9394415 [PubMed - indexed for MEDLINE]

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