Justin Grobe, Ph.D. (2006-2012)
Assitant Professor of Pharmacology, University of Iowa
Publications from Sigmund Lab
Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A Brain Leptin-Renin Angiotensin System Interaction in the Regulation of Sympathetic Nerve Activity. Am J Physiol Heart Circ Physiol. 2012 May 18. [Epub ahead of print]
Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Arch. 2012 Apr 12. [Epub ahead of print]
Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1067-77.
Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension. 2011 Mar;57(3):600-7.
Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiol Genomics. 2011 Mar 29;43(6):286-94.
Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab. 2010 Nov 3;12(5):431-42.
Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension. 2010 Nov;56(5):981-7.
Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7.
Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1325-6.
Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.Physiology (Bethesda). 2008 Aug;23:187-93. Review.
Representative Publications From Graduate Work
1: | Grobe JL, Mecca AP, Mao H, Katovich MJ. | |
Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt
model of hypertension. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2417-23. Epub 2006 Jan 13. |
2: | Grobe JL, Katovich MJ. | |
Alterations in aortic vascular reactivity to angiotensin 1-7
in 17-beta-estradiol-treated female SD rats. Regul Pept. 2006 Jan 15;133(1-3):62-7. Epub 2005 Oct 10. |
3: | Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. | |
Protection from angiotensin II-induced cardiac hypertrophy
and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp Physiol. 2005 Sep;90(5):783-90. Epub 2005 Jul 27. |
4: | Katovich MJ, Grobe JL, Huentelman M, Raizada MK. | |
Angiotensin-converting enzyme 2 as a novel target for gene
therapy for hypertension. Exp Physiol. 2005 May;90(3):299-305. Epub 2005 Jan 7. Review. |
5: | Grobe J, Rowland N, Katovich M. | |
Role of angiotensin II and the subfornical organ in the
pharmacological actions of ethanol. Alcohol Alcohol. 2004 Sep-Oct;39(5):410-7. Epub 2004 Aug 2. |
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