Selected Publications


Endothelial and cardiomyocyte PI3Kß divergently regulate cardiac remodelling in response to ischaemic injury.
Chen, X., Zhabyeyev, P., Azad, A. K., Wang, W., Minerath, R. A., DesAulniers, J., Grueter, C. E., Murray, A. G., Kassiri, Z., Vanhaesebroeck, B. & Oudit, G. Y. Cardiovascular research, 115(8), 1343-1356. PMID: 30496354.

Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure.
Minerath, R. A., Hall, D. D. & Grueter, C. E. Heart failure reviews. PMID: 30972522.

Regulation of cardiac transcription by thyroid hormone and Med13.
Minerath, R. A., Dewey, C. M., Hall, D. D. & Grueter, C. E. (2019). Journal of molecular and cellular cardiology, 129, 27-38. PMID: 30769017.

Disruption of cardiac Med1 inhibits RNA polymerase II promoter occupancy and promotes chromatin remodeling.
Hall, D. D., Spitler, K. M. & Grueter, C. E. (2019). American journal of physiology. Heart and circulatory physiology, 316(2), H314-H325. PMID: 30461303.


E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator.
Guo, A., Wang, Y., Chen, B., Wang, Y., Yuan, J., Zhang, L., Hall, D., Wu, J., Shi, Y., Zhu, Q., Chen, C., Thiel, W. H., Zhan, X., Weiss, R. M., Zhan, F., Musselman, C. A., Pufall, M., Zhu, W., Au, K. F., Hong, J., Anderson, M. E., Grueter, C. E. & Song, L. S. (2018). Science (New York, N.Y.), 362(6421). PMID: 30409805.


Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure. (Article Highlight | The Scientist)
Hall DD, Ponce JM, Chen B, Spitler KM, Alexia A, Oudit GY, Song LS, Grueter CE. JCI Insight. 2017 Aug 3;2(15). pii: 92476. doi: 10.1172/jci.insight.92476.
PMID: 28768905

Cardiac Med1 deletion promotes early lethality, cardiac remodeling and transcriptional reprogramming.
Spitler KM, Ponce JM, Oudit GY, Hall DD, Grueter CE. Am J Physiol Heart Circ Physiol. 2017 Feb 3:ajpheart.00728.2016. doi: 10.1152/ajpheart.00728.2016.
PMID: 28159809


Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers.
Dewey CM, Spitler KM, Ponce JM, Hall DD, Grueter CE. J Am Heart Assoc. 2016 May 31;5(6).
PMID: 27247337


MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN. EMBO Mol Med. 2014 Nov 24;6(12):1610-21.
PMID: 25422356

Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor.
Long C, Grueter CE, Song K, Qin S, Qi X, Kong YM, Shelton JM, Richardson JA, Zhang CL, Bassel-Duby R, Olson EN. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11521.
PMID: 25049392


Mediator complex dependent regulation of cardiac development and disease.
Grueter CE. Genomics Proteomics Bioinformatics. 2013 Jun;11(3):151-7.
PMID: 23727265


Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*.
Carrer M, Liu N, Grueter CE, Williams AH, Frisard MI, Hulver MW, Bassel-Duby R, Olson EN.
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15330-5
PMID: 22949648

A cardiac microRNA governs systemic energy homeostasis by regulation of MED13.
Grueter CE, van Rooij E, Johnson BA, DeLeon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN. Cell. 2012 Apr 27;149(3):671-83.
PMID: 22541436

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice.
Moresi V, Carrer M, Grueter CE, Rifki OF, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1649-54.
PMID: 22307625


The gamma isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption.
Backs J, Stein P, Backs T, Duncan FE, Grueter CE, McAnally J, Qi X, Schultz RM, Olson EN.
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):81-6.
PMID: 19966304


The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7.
PMID: 19179290


Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits.
Grueter CE, Abiria SA, Wu Y, Anderson ME, Colbran RJ. Biochemistry. 2008 Feb 12;47(6):1760-7.
PMID: 18205403

Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
Khoo MS, Grueter CE, Eren M, Yang J, Zhang R, Bass MA, Lwin ST, Mendes LA, Vaughan DE, Colbran RJ, Anderson ME. J Mol Cell Cardiol. 2008 Feb;44(2):405-10.
PMID: 18048055


CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction.
Grueter CE, Colbran RJ, Anderson ME. J Mol Med (Berl). 2007 Jan;85(1):5-14.
PMID: 17119905


Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME. Circulation. 2006 Sep 26;114(13):1352-9.
PMID: 16982937

L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII.
Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ. Mol Cell. 2006 Sep 1;23(5):641-50.
PMID: 16949361

Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition.
Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME. J Mol Cell Cardiol. 2006 Feb;40(2):213-23.
PMID: 16413575


A dynamic alpha-beta inter-subunit agonist signaling complex is a novel feedback mechanism for regulating L-type Ca2+ channel opening.
Zhang R, Dzhura I, Grueter CE, Thiel W, Colbran RJ, Anderson ME. FASEB J. 2005 Sep;19(11):1573-5.
PMID: 15994413

Calmodulin kinase II inhibition protects against structural heart disease.
Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Nat Med. 2005 Apr;11(4):409-17. Epub 2005 Mar 27.
PMID: 15793582

Complete List of Publications