People

Principal Investigator


Chad Grueter, Ph.D.

Chad Grueter, Ph.D.

Educational Background:
University of Texas Southwestern Medical Center, Postdoctoral Fellow
Ph.D. Molecular Physiology, Vanderbilt University
M.S. Biology, University of Illinois at Springfield
B.S. Biology, Illinois College

chad-grueter@uiowa.edu

Affiliations:
Department of Internal Medicine, Division of Cardiology
Abboud Cardiovascular Research Center
Fraternal Order of Eagles Diabetes Center
Papajohn Biomedical Institute
Interdisciplinary Graduate Program in Genetics

Faculty


Duane Hall, Ph.D.

Duane Hall, Ph.D.

Research Area:
CDK8 is the founding kinase associated with Mediator, having both activating and repressive activity on transcription. Using animal models, molecular biology, cell biology, and biochemistry, I am determining the role of CDK8 in cardiac function, adaptation to disease-related stresses, and development.

Educational Background:
University of Iowa, Postdoctoral Fellow
Ph.D. Biomolecular Chemistry, University of Wisconsin-Madison
B.S. Chemistry, Univesity of Nebraska-Kearney

About Me:
Exhilarating extramural endeavors encompass engrossed photography, extemporaneous relaxation, exploratory gustation, entranced husbandry, extolling fatherhood, excessive alliteration, etc.

duane-hall@uiowa.edu

Postdoctoral Fellows


Katie Spitler ,Ph.D.

Katie Spitler, Ph.D.

Research Area:
I study the role of Mediator complex subunit Mediator 1 (MED1) during cardiac postnatal development and cardiac function. I use a cardiac-specific knockout mouse as well as an inducible cardiac-specific knockout mouse to identify transcriptional signaling pathways that MED1 regulates, contributing to cardiac function.

Educational Background:
Ph.D. Physiology, Georgia Regents University
B.A. Biochemistry, Drake University

About Me:
I am an enthusiastic science minion who enjoys pipetting 384-well plates, color changing reactions, and, when opportunity arises, spending time outside.

kathryn-spitler@uiowa.edu

Colleen M. Dewey : Postdoctoral Scholar

Colleen M. Dewey, Ph.D.

Research Area:
I’m investigating how the kinase submodule of Mediator alters gene expression and cellular signaling networks in mice during chronic exposure to high fat diet leading to heart disease.

Educational Background:
Ph.D. Neuroscience, University of Texas Southwestern Medical Center
B.S. Bioengineering, University of Illinois at Urbana-Champaign
B.S. Biochemistry, University of Illinois at Urbana-Champaign

About Me:
In addition to science, I enjoy gardening, puzzles, podcasts and road trips.

colleen-johnson@uiowa.edu

Graduate Students


Rachel Minerath

Rachel Minerath

Research Area:
Using mouse models and pharmacological approaches, I’m studying the role of Mediator submodule kinase CDK19 in cardiac function and transcriptional activation/repression associated with cardiac disease states.

Educational Background:
B.S. Microbiology, University of Wisconsin-Oshkosh

About Me:
Outside of lab, I enjoy traveling, and I especially love the French Riviera. I also enjoy tennis, puppies, and coffee. Most importantly, I am a shamelessly obsessive Green Bay Packers fan.

rachel-minerath@uiowa.edu

Jessica Ponce

Jessica Ponce

Research Area:
The Cyclin C protein is a component of the mediator complex and coactivator involved in regulating gene transcription through interactions with CDK8. The focus of my project is to investigate an additional role of Cyclin C in regulating stress-induced gene induction and mitochondrial hyperfission in the cardiovascular system.

Educational Background:
M.S. Chemistry, California State University-Los Angeles
B.S. Biology, California State University-Los Angeles

About Me:
Outside of scientific endeavors, I enjoy being outdoors, playing sports, planning to take over the world, and spending time with my family.

jessica-ponce@uiowa.edu

Undergraduate Students


Adrianne Alexia

Adrianne Alexia

Research Area:
I am focused on the Mediator complex subunit, Mediator 1 (MED1). I am particularly interested on the role of MED1 during development and adult cardiac stress.

Educational Background:
B.S. Biochemistry, University of Iowa

About Me:
Besides being a science and health nerd, I run for the University of Iowa Track and Field Team. I enjoy being outside and going on adventures. Coffee addict since 2010.

adrianne-alexia@uiowa.edu

Technical Staff


Ines Martins

Ines Martins

Research Area:
I perform cardiovascular surgeries (TAB and MIR) in murine models. My experience includes gene transfer, intracranial surgeries in murine models, and molecular biology techniques.

Educational Background:
B.S. Microbiology, University of Iowa

About Me:
When I am not spending time with mice, I enjoy sewing, gardening, watching sports, and cooking gourmet dinners for family and friends.

ines-martins@uiowa.edu