Current Projects


     The Bassuk laboratory is interested in understanding the basic mechanisms underlying both normal and disordered development of the nervous system. Our approach to these issues includes investigating the genetics of human neural tube defects (NTDs) and familial epilepsies, and elucidating the biology regulating neural stem cell development. The techniques used in our laboratory include genome wide linkage analysis (GWA), association studies, comparative genomic hybridization (CGH), copy number variation (CNV) analysis, transgenic mouse production, and cell culture. As part of our studies we have collected DNA samples from over 2000 patients and family members with congenital nervous system malformations, and several large families with autosomal recessive epilepsy syndromes.
The Ferguson laboratory is interested in the genetic aspects of inflammatory disorders. Current research projects focus on determining the genetic basis of Chronic Recurrent Multifocal Osteomyelitis, SAPHO Syndrome and Lupus.
Chronic Recurrent Multifocal Osteomyelitis (CRMO)
Systemic Lupus Erythematosus (SLE)