The University of Iowa Carver College of Medicine
Electron Spin Resonance Facility
Garry Buettner, Ph.D.
Research Interests
- The fundamental chemistry and biochemistry of vitamins C and E
- Nitric Oxide as a membrane antioxidant
- The use of the ascorbate radical as a marker for free radical oxidative stress
- Redox Biology, the chemisty redox state
- Free radicals in membrane lipid peroxidation
- Photodynamic Cancer Therapy
- The role of metals in free radical oxidations. We were the first to demonstrate that adventitious iron can change the results observed in free radical experiments. This work has been honored as a Citation Classic.
[Citation Commentary] - The chemistry of EPR spin trapping
- Oxidative stress from the environment
Example Publications
- Hummel SG, Fischer AJ, Maritin SM, Schafer FQ, Buettner GR. (2006) Nitric oxide as a cellular antioxidant. A little goes a long way. Free Radic Biol Med. 40: 501-506.
[Article PDF][DOI Article] - Yoon SS. Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang Sh, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. (2006) Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. The Journal of Clinical Investigation. 116: 436-446.
[DOI Article] - Chen Q. Espey MG. Krishna MC. Mitchell JB. Corpe CP. Buettner GR. Shacter E. Levine M. (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc of the Nat Acad of Sci of the U.S.A. 102(38):13604-9.
[Article PDF][DOI Article] - Venkataraman S, Jiang X, Weydert CJ, Zhang Y, Zhang HJ, Prabhat C Goswami PC, Ritchie JM, Oberley LW, Buettner GR. (2005) Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells, Oncogene, 24: 77-89.
[Article PDF][DOI Article] - Schafer FQ, Buettner GR. (2001) Redox state of the cell as viewed though the glutathione disulfide/glutathione couple. Free Radic Biol Med. 30:1191-1212.
[Abstract] [Article PDF]
Biographical Information
Honors, Awards & Organizations
- Distinguished Service Award, 2006, Society for Free Radical Biology and Medicine
- Staples Distinguished Lecturer, 200, The University of Maine
- Master Teaching Award, 1999, Society for Free Radical Biology and Medicine
- Citation Classic selection by the Institute for Scientific Information, the publishers of Current Contents for: Oberley LW and Buettner GR (1979) The role of superoxide dismutase in cancer: A review. Cancer Research 39: 1141-1149.
[Citation Commentary] [Abstract] [Article PDF] - Citation Classic selection by the Institute for Scientific Information, the publishers of Current Contents for: Buettner GR, Oberley LW, and Leuthauser SWHC. (1978) The effect of iron on the distribution of superoxide and hydroxl radicals as seen by spin trapping and on the superoxide dismutase assay. Photochem Photobiol 28: 693-695.
[Citation Commentary] [Abstract] [PDF] - Citation Classic selection by the Institute for Scientific Information, the publishers of Current Contents for: Buettner GR and Oberley LW. (1978) Considerations in the spin trapping of superoxide and hydroxyl radicals in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide. Biochem Biophys Res Commun 83: 64-74.
[Citation Commentary] [Abstract] [PDF] - Editorial Board, 1995-Present, Archives Biochemistry and Biophysics
- Editorial Board, 1995-Present, Free Radicals in Biology and Medicine
- Editorial Board, 1999-2004, Free Radical Research
- Fulbright Scholar, 1985-1987, GSF Research Institute, Munich, Germany
Education
- Ph.D. Chemistry, The University of Iowa, 1976
- M.S. Chemistry, The University of Iowa, 1969
- B.A. Chemistry, University of Northern Iowa, 1967
Post Graduate Education
- Fulbright Scholar GSF Research Institute, Munich, Germany, 1985-1987
- NRSA Senior Fellow NIEHS, North Carolina, 1984-1985
- NRSA Post Doctoral Fellow Radiation Research Lab, The University of Iowa, 1976-1978
Favorite Quote
It's kind of fun to do the impossible." --Walt Disney