D-Dimer

Label Mnemonic:	DDI
Epic code:	LAB602
Order form:	Laboratory Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	85380

Specimen(s):

Citrated Plasma More information

Collection Medium:

Light Blue top tube 1.8 mL (Na Citrate)

Minimum:

Full draw; 1.8 mL in light blue-top (3.2% sodium citrate) tube. Mix well.

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

<0.50 mg/L Fibrinogen Equivalent Units (FEU)

Comments:

D-dimer units of measurement are mg/L FEU, where FEU = fibrinogen equivalent units. In conjunction with a non-high clinical probability assessment, a D-dimer result below the accepted cut-off (< 0.5 mg/L FEU) excludes deep vein thrombosis and pulmonary embolism with high sensitivity. D-dimer values above the reference range (> 1.14 mg/L FEU) are not specific and may be seen in deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, fibrinolysis, recent surgery, active bleeding, hematomas, trauma, pregnancy, liver disease, inflammation, and malignancy.

Updated to Siemens Innovance D-Dimer assay on 7/14/2020

Methodology:

Immunoturbidimetric

Sample Processing:

Double-centrifuge specimen to prepare platelet-free plasma.
Immediately centrifuge specimen at 3500 RPM for 12 minutes.
Using a plastic transfer pipette, carefully remove plasma from cells avoiding the platelet/buffy coat.
Place plasma into a labeled plastic tube.
Centrifuge plasma again at 3500 RPM for 12 minutes.
Remove the top of the plasma and place into a labeled plastic tube.
Freeze double-spun plasma within 4 hours of collection time at -20 degrees C or below.

Sample Storage:

Freeze specimen immediately.

Transport Instructions:

Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place dry ice on top of specimen in Styrofoam container.
Samples received thawed will be cancelled.

See Additional Information:
Impact of Common Anticoagulants on Coagulation Tests