D-Dimer
Label Mnemonic: | DDI |
Epic code: | LAB602 |
Order form: | Laboratory Requisition |
Supply order: | Supply Order Form |
Billing: | Billing Policies |
CPT code: | 85380 |
Specimen(s):
Citrated Plasma
More information
Collection Medium:
![]() |
Light Blue top tube 1.8 mL (Na Citrate) |
Minimum:
Full draw; 1.8 mL in light blue-top (3.2% sodium citrate) tube. Mix
well.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
<0.50 mg/L Fibrinogen Equivalent Units (FEU)
Comments:
D-dimer units of measurement are mg/L FEU, where FEU = fibrinogen
equivalent units. In conjunction with a non-high clinical
probability assessment, a D-dimer result below the accepted cut-off
(< 0.5 mg/L FEU) excludes deep vein thrombosis and pulmonary
embolism with high sensitivity. D-dimer values above the reference
range (> 1.14 mg/L FEU) are not specific and may be seen in deep
venous thrombosis, pulmonary embolism, disseminated intravascular
coagulation, fibrinolysis, recent surgery, active bleeding,
hematomas, trauma, pregnancy, liver disease, inflammation, and
malignancy.
Updated to Siemens Innovance D-Dimer assay on 7/14/2020
Updated to Siemens Innovance D-Dimer assay on 7/14/2020
Methodology:
Immunoturbidimetric
Sample Processing:
Double-centrifuge specimen to prepare platelet-free plasma.
Immediately centrifuge specimen at 3500 RPM for 12 minutes.
Using a plastic transfer pipette, carefully remove plasma from cells avoiding the platelet/buffy coat.
Place plasma into a labeled plastic tube.
Centrifuge plasma again at 3500 RPM for 12 minutes.
Remove the top of the plasma and place into a labeled plastic tube.
Freeze double-spun plasma within 4 hours of collection time at -20 degrees C or below.
Immediately centrifuge specimen at 3500 RPM for 12 minutes.
Using a plastic transfer pipette, carefully remove plasma from cells avoiding the platelet/buffy coat.
Place plasma into a labeled plastic tube.
Centrifuge plasma again at 3500 RPM for 12 minutes.
Remove the top of the plasma and place into a labeled plastic tube.
Freeze double-spun plasma within 4 hours of collection time at -20 degrees C or below.
Sample Storage:
Freeze specimen immediately.
Transport Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal
bag.
Place dry ice on top of specimen in Styrofoam container.
Samples received thawed will be cancelled.
Place dry ice on top of specimen in Styrofoam container.
Samples received thawed will be cancelled.