JAK2 Exons 12, 13, and 14 including V617F Mutation Analysis with Interpretation

Label Mnemonic:	JAK2BM
Epic code:	LAB8031
Order form:	Comprehensive Hematopathology Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	81270

Specimen(s):

Bone Marrow Aspirate

Collection Medium:

Pink top tube 6 mL (K2-EDTA)

Minimum:

2 mL bone marrow aspirate

Testing Schedule:

Weekly

Turn Around Time:

7-10 working days upon receipt

Reference Range:

Direct detection of G-T transversion at position 1849 of the Janus kinase 2 locus, giving rise to a Valine-to-Phenylalanine substitution at position 617 (JAK2 V617F mutation).

Interpretive Data:

Refer to report

Comments:

This test is useful in the diagnosis of myeloproliferative disorders.

Note: Exon 14 includes the common V617F variant.

Methodology:

Massively parallel next generation DNA sequencing by synthesis, using semiconductor technology.

Sample Processing:

Label transport tube with two patient identifiers, date and time of collection.
Patient's age and sex is required on requisition for processing.
Relevant clinical information must be submitted with specimen in order to provide correct interpretation of test results.
Do Not Centrifuge.

Sample Storage:

Refrigerate.

Transport Instructions:

Place requisition into outside pocket of bag.
Recommend early AM overnight shipping or equivalent if not on courier service.
Ship refrigerated.