Tacrolimus
| Label Mnemonic: | TACRO |
| Epic code: | LAB908 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 80197 |
Specimen(s):
Whole Blood
Collection Medium:
|
| Lavender top tube 3 mL (EDTA) |
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection
containers.
Minimum:
Preferred Minimum: 3 mL whole blood in lavender top tube (EDTA) or
ONE lavender top (EDTA) microtube for pediatric patients, mix well.
Testing Schedule:
Results are available 1200 Monday-Sunday. Samples need to be in lab
by 0900 for results at 1200 (daily).
Turn Around Time:
24 hours (upon receipt in laboratory)
Interpretive Data:
Analysis performed using the Roche Diagnostics Elecsys Tacrolimus
immunoassay on the Roche e602 platform. The general therapeutic
range for tacrolimus is 5-20 ng/mL. The optimal therapeutic range
for a given patient may differ from this suggested range based on
the indication for therapy, treatment phase (initiation or
maintenance), use in combination with other drugs, time of specimen
collection relative to prior dose, type of transplanted organ,
and/or the therapeutic approach of the transplant center.
Comments:
Analysis performed using the Abbott Diagnostics Tacrolimus
immunoassay on the Architect platform. The general therapeutic range
for tacrolimus is 5-20 ng/mL. The optimal therapeutic range for a
given patient may differ from this suggested range based on the
indication for therapy, treatment phase (initiation or maintenance),
use in combination with other drugs, time of specimen collection
relative to prior dose, type of transplanted organ, and/or the
therapeutic approach of the transplant center. Tacrolimus whole
blood concentrations can be measured by either immunoassay or
chromatographic methodologies. These two methodologies are not
directly interchangeable, and the measured tacrolimus whole blood
concentration depends on the methodology used. Reference ranges may
vary according to the specific immunoassay or HPLC-MS/MS test.
Generally, immunoassays have been reported to have a positive bias
relative to HPLC-MS/MS assays due to the detection of antibody
cross- reactivity with tacrolimus metabolites.
Methodology:
Chemiluminescent Microparticle Immunoassay
Instructions:
Trough sample preferred.
Sample Processing:
Submit whole blood in original container.
DO NOT CENTRIFUGE.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample Storage:
Refrigerate.
Transport Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal
bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.