Clozapine Drug Level
| Label Mnemonic: | CLOZ |
| Epic code: | LAB2886 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
6240-8 RCP
356-8593
Separate serum from cells as soon as possible.
Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
 |
| Red top tube 5 mL (Clot Activator) |
Preferred Minimum: 1.0 mL serum
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Submit specimen to laboratory as soon as possible after collection.1-5 days upon receipt at reference laboratory
| Components | Reference Interval |
|---|---|
| Clozapine-N-Oxide, S/P, Quant | Therapeutic and toxic ranges are not well established |
| Norclozapine, S/P, Quant | Therapeutic and toxic ranges are not well established |
| Clozapine, S/P, Quant | Therapeutic Range: 350-600 ng/mL Toxic: Greater than or equal to 1000 ng/mL |
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to clozapine therapy may include tachycardia, hematologic disorders, neuroleptic malignant syndrome, elevation of liver enzymes, seizures, and tardive dyskinesia. Therapeutic and toxic ranges are not well established in children.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Gel separator tubes are not recommended.