Copper, 24-Hour Urine
| Label Mnemonic: | CUU |
| Epic code: | LAB380 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
6240-8 RCP
356-8593
Refrigerate during 24 hr collection in plastic container. Reference laboratory studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.
Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.
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| Urine - 24 hour/timed plastic urine container |
Preferred Minimum: 8 mL urine from a well-mixed, refrigerated, 24 hr urine collection.
Absolute Minimum: 1 mL urine from a well-mixed, refrigerated, 24 hr urine collection.
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.
1–5 days upon receipt at reference laboratory
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
| Components | Reference Interval |
|---|---|
| Copper, Urine - per 24h | 3.0–45.0 microg/d |
| Copper, Urine - ratio to CRT | 10.0–45.0 microg/g CRT |
Individuals with symptomatic Wilson disease usually excrete more than 100 ug copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, and some medications, and contaminated specimens.
Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Urine Tests Requiring Preservatives, Refrigeration or Special Containers