Cytomegalovirus Antiviral Drug Resistance by Sequencing
| Label Mnemonic: | CMVAVR |
| Epic code: | LAB8741 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Plasma
Collection Medium:
 |
| Pink top tube 6 mL (K2-EDTA) |
Minimum:
Please submit most recent viral load and test date, if available.
Preferred Minimum: 3 mL EDTA plasma
Absolute Minimum: 1.5 mL EDTA plasma
Preferred Minimum: 3 mL EDTA plasma
Absolute Minimum: 1.5 mL EDTA plasma
Rejection Criteria:
Heparinized specimens.
Turn Around
Time:
2-3 days upon receipt at reference laboratory
Interpretive Data:
Codons 457-630 of the UL97 gene and codons 393-1000 of the
UL54 gene are sequenced. Mutations associated with resistance to
ganciclovir, cidofovir, and foscarnet are reported. Mutations in viral
sub-populations below 20 percent of total may not be detected.
The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Comments:
This test determines antiviral drug resistance to cidofovir, foscarnet
sodium, and ganciclovir.
Note: This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.
Note: This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.
Methodology:
Polymerase Chain Reaction/Sequencing
CPT Code:
87910