Arsenic, Random Urine with Reflex to Fractionated

Label Mnemonic: ARSUR
Epic code: LAB8527
Downtime form: Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
356-8593
Specimen(s):
Random Urine
Specimen Instructions:

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications (upon the advice of their physician), and avoid shellfish and seafood for 48 to 72 hours. High concentrations of iodine may interfere with elemental testing. Collection of urine specimens from patients receiving iodinated or gadolinium-based contrast media should be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collection Medium:
Urine (Random)-BD Vacutainer®, no additive yellow top
Minimum:

Preferred Minimum: 8 mL random urine
Absolute Minimum: 2 mL random urine

Rejection Criteria:

Acid preserved urine. Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media.

Turn Around Time:

1–10 days upon receipt at reference laboratory

Reference Range:
Components Reference Interval
Arsenic, Urine - per volume Less than or equal to 34.9 microg/L
Arsenic, Urine - ratio to CRT Less than or equal to 29.9 microg/g CRT

 

Interpretive Data:

The ACGIH Biological Exposure Index (BEI) for arsenic in urine is 35 ug/L measured at the end of the work week. The ACGIH BEI is based on the sum of inorganic and methylated species. For specimens with elevated total arsenic results, fractionation is automatically performed to determine the proportions of inorganic, methylated and organic species. Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended.

 

Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended.

Methodology:

Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)

CPT Code:
82175; if reflexed, add 82175