Herpesvirus 7 (HHV-7) Quant Other

Label Mnemonic:	HHV7O
Epic code:	LAB7899
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Various Sample Types

Collection Medium:

Sterile container

Minimum:

Bronchial Lavage/Bronchial Wash: 2 mL, collected in sterile, 
screw-cap tube

CSF: 2 mL submitted in sterile, screw-cap tube

Tissue: Place a minimum of 5 mg fresh tissue (approximately 1/2 of a 
pencil eraser size) in a sterile, screw top container. Do not add 
water, saline or other fluid media to container. Formalin fixed, 
paraffin embedded tissue will not be accepted.

Tracheal Aspirate/Tracheal Wash: 2 mL collected in a sterile, screw top 
tube

Rejection Criteria:

Whole blood frozen, specimens received in trap containers, or specimen types other than those listed.

Turn Around Time:

24 hours upon receipt in reference laboratory.

Reference Range:

Not Detected

Comments:

HHV-7 is detectable in a variety of transplant settings, both HSCT 
and solid organ. Direct effects of HHV-7 include fever, rash, 
myelosuppression, encephalitis, and pneumonitis. Potentially more 
important are the indirect effects HHV-7 has on CMV disease, invasive 
fungal disease, and allograft dysfunction. Quantitative HHV-7 DNA PCR 
can be used to document the presence of the virus as well as track the 
course of infection.

The primers and probes used in this assay are specific for known 
strains of HHV-7 based on similarity search algorithms. Additionally, 
no cross reactivity was detected when tested against adenoviruses, BKV, 
CMV, EBV, HSV-1, HSV-2, HHV-6 variant A, HHV-6 variant B, HHV-8, JCV, 
parvovirus B19, SV-40, and VZV.

Methodology:

Quantitative Real-Time PCR

CPT Code:

87799