Coccidioides Antibody, CF/ID

Label Mnemonic:	COCCI
Epic code:	LAB2894
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Specimen Instructions:

Mark specimens plainly as "acute" or "convalescent."

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 2 mL serum
Absolute Minimum: 0.6 mL serum

Rejection Criteria:

Other body fluids. Hemolyzed, icteric, or lipemic specimens.

Turn Around Time:

3-6 days upon receipt at reference laboratory

Reference Range:

Coccidioides Antibody by CF
  < 1:2

Coccidioides immitis Antibodies by Immunodiffusion
  None detected

Coccidioides Antibody, IgG by ELISA
  0.9 IV or less    Negative - No significant level of Coccidioides IgG
                    antibody detected.

  1.0-1.4 IV        Equivocal - Questionable presence of Coccidioides
                    IgG antibody detected.  Repeat testing in 10-14
                    days may be helpful.

  1.5 IV or greater Positive - Presence of IgG antibody to
                    Coccidioides detected, suggestive of current or
                    past infection.

Coccidioides Antibody, IgM by ELISA
  0.9 IV or less    Negative - No significant level of Coccidioides
                    IgM antibody detected.

  1.0-1.4 IV        Equivocal - Questionable presence of Coccidioides
                    IgM antibody detected.  Repeat testing in 10-14
                    days may be helpful.

  1.5 IV or greater Positive - Presence of IgM antibody to
                    Coccidioides detected, suggestive of current or
                    recent infection.

Interpretive Data:

Refer to individual components.

For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Methodology:

Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay (ELISA)

CPT Code:

86635 Cocci Ab (CF)
86635 Cocci Ab (ID)
86635 Cocci Ab, IgG (EIA)
86635 Cocci Ab, IgM (EIA)