Low Density Cholesterol Measured

Label Mnemonic:	LDL
Epic code:	LAB102
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Plasma

Collection Medium:

Plasma Separator Tube 4.5 mL

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3 mL whole blood from light green top tube or ONE Microtainer^Â®.

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

< 130- mg/dL (Approved by NCEP, National Cholesterol Education Program for adults 18 years and older)
Normal - <100 mg/dL
Above Normal - 100-129 mg/dL
Borderline High - 130-159 mg/dL
High - 160-189 mg/dL
Very High - ≥190 mg/dL

The Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents has set the following guidelines for lipids in a context of cardiovascular risk for children 2 to 17 years old:

LDL CHOLESTEROL

Acceptable: <110 mg/dL

Borderline High: 110-129 mg/dL

High: > or =130 mg/dL

Reference values have not been established for patients who are younger than 24 months of age.

Comments:

Fasting for at least 8 hours prior to collection is recommended. Non- fasting sample can be used, but they are slightly lower than fasting results. Correlation between calculated LDL and measured LDL is very good. Measured can be used for LDL (measured) non-fasting samples with Triglycerides > 400 mg/dL.

This test is also performed in the Iowa River Landing (IRL) clinical laboratory (for specimens drawn at that site).

References

Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1-executive summary. J Clin Lipidol. 2014;8(5):473-488. doi: 10.1016/j.jacl.2014.07.007
Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report. Pediatrics. 2011 Dec;128 Suppl 5(Suppl 5):S213-S256. doi: 10.1542/peds.2009-2107C

Test Limitations:

In rare cases, elevated immunoglobulin concentrations cause falsely elevated LDL values.

Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 1000 (approximate triglycerides concentration: 2000 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL).

Methodology:

Enzymatic

CPT Code:

83721

See Additional Information:
Fasting Specimen Requirements