Amino Acids, Quantitative

Label Mnemonic:	AAQTU
Epic code:	LAB355
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Random Urine

Specimen Instructions:

Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information. Patient's age is required on request form for processing.

Collection Medium:

Yellow top round bottom tube (no additive)

Minimum:

2 mL aliquot from random urine

Delivery Instructions:

Deliver to laboratory immediately after collection.

Testing Schedule:

Tests performed Monday through Friday only.

Turn Around Time:

3 days upon receipt at reference laboratory (not reported on Saturday or Sunday)

Reference Range:

                                         Age Groups
Urine Amino Acid     < or =    13-35    3-6      7-8     9-17    > or =
Reference Values     12 Mo      Mo       Y        Y       Y       18 Y
(nmol/mg creatine)   (n=515)  (n=210)  (n=197)  (n=74)  (n=214)  (n=835)
------------------------------------------------------------------------
Phosphoserine        <1       <1       <1       <1      <1       <1     
Phosphoethanolamine  15-341   33-342   19-164   12-118  <88      <48    
Taurine              37-8300  64-3255  76-3519  50-2051 57-2235  24-1531
Asparagine           25-1000  62-884   28-412   38-396  22-283   25-238
Serine               18-4483  284-1959 179-1285 153-765 105-846  97-540
Hydroxyproline       <2536    <89      <46      <19     <22      <15
Glycine              362-     627-     412-     449-    316-     229-
                     18614    6914     5705     4492    4249     2989
Glutamine            139-     263-     152-     164-    188-     93-
                     2985     2979     1325     1125    1365     686
Aspartic Acid        <64      <56      <30      <9      <11      <10
Ethanolamine         282-     256-     193-     137-    158-     95-
                     3782     947      643      564     596      471
Histidine            145-     427-     230-     268-    134-     81-
                     3833     3398     2635     2147    1983     1128
Threonine            25-1217  55-763   30-554   25-456  37-418   31-278
Citrulline           <72      <57      <14      <9      <14      <12
Sarcosine            <75      <12      <9       <2      <3       <3
Beta-Alanine         <219     <92      <25      <25     <49      <52
Alanine              93-3007  101-1500 64-1299  44-814  51-696   56-518
Glutamic Acid        <243     12-128   <76      <39     <62      <34
1-Methylhistidine    17-419   18-      10-      19-     12-      23-
                              1629     1476     1435    1549     1339
3-Methylhistidine    88-350   86-330   56-316   77-260  47-262   70-246
Argininosuccinic     <77      <48      <37      <24     <69      <15
  Acid
Carnosine            27-1021  16-616   18-319   <161    <109     <35
Anserine             <277     <820     <398     <141    <369     <38
Homocitrulline       <295     11-158   <71      <62     <33      <30
Arginine             10-560   20-395   14-240   <134    <153     <114
Alpha-aminoadipic    10-275   15-324   10-135   <84     <76      <47
  Acid
Gamma Amino-n-       <25      <13      <11      <6      <5       <5
  butyric Acid
Beta-                18-3137  <980     15-1039  24-511  11-286   <301
  aminoisobutyric Acid
Alpha-amino-n-       <63      <56      <38      <30     <31      <19
  butyric Acid
Hydroxylysine        <150     <57      <34      <26     <31      <12
Proline              28-2029  <119     <78      <20     <28      <26
Ornithine            <265     <70      <44      <17     <18      <25
Cystathionine        <302     <56      <26      <18     <44      <30
Cystine              12-504   11-133   <130     <56     <104     10-98
Lysine               19-1988  25-743   14-307   17-276  10-240   15-271
Methionine           <41      <41      <25      <23     <20      <16
Valine               11-211   11-211   <139     16-91   <75      11-61
Tyrosine             39-685   38-479   23-254   22-245  12-208   15-115
Isoleucine           <86      <78      <62      <34     <28      <22
Leucine              <200     15-167   12-100   13-73   <62      <51
Phenylalanine        14-280   34-254   20-150   21-106  11-111   13-70
Tryptophan           14-315   14-315   10-303   10-303  15-229   18-114
Allo-isoleucine      <29      <10      <8       <8      <8       <7

Interpretive Data:

When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, elements of differential diagnosis, recommendations for additional biochemical testing and in vitro confirmatory studies (enzyme assay, molecular analysis), name and phone number of key contacts who may provide these studies at the reference laboratory or elsewhere, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.

Comments:

Useful For:
Suggests clinical disorders or settings where the test may be helpful evaluating patients with possible inborn errors of metabolism

May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns

Methodology:

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), Quantitative

Includes quantitation of the following amino acids: taurine, threonine, serine, asparagine, glutamic acid, glutamine, proline, glycine, alanine, citrulline, a-aminoadipic acid, a-amino-n-butyric acid, valine, cystine, cystathionine, methionine, isoleucine, leucine, tyrosine, phenylalanine, b-alanine, b-aminoisobutyric acid, ornithine, lysine, 1-methylhistidine, histidine, 3-methylhistidine, carnosine, argininosuccinic acid, allo-isoleucine, homocitrulline, and arginine.

CPT Code:

82139

See Additional Information:
Specimens Requiring Immediate Delivery
Urine Tests Requiring no Preservatives