CURRICULUM VITAE
Craig T. Morita, M.D., Ph.D.

I. Personal Data

A. Citizenship Status: U.S.A.

II. Education

Year Degree Institution
1977 A.B. University of California, Berkeley, California
1985 M.D. University of California School of Medicine, San Francisco, California
1985 Ph.D. (Immunology) University of California School of Medicine, San Francisco, California

III.Post-Graduate Education

Year Position Institution
1985-86 Intern Internal Medicine, University of California School of Medicine, San Diego, California
1986-88 Resident Internal Medicine, University Hospital, Boston University School of Medicine, Boston, Massachusetts
1988-91 Research Fellow Medicine, Harvard Medical School, Boston, Massachusetts
1988-92 Research Fellow, Rheumatology Department of Rheumatology and Immunology, Brigham and Women’s Hospital, Boston, Massachusetts

IV. Academic Appointments

Year Position Institution
1991-97 Instructor Department of Medicine, Harvard Medical School, Boston, Massachusetts
1997-1998 Assistant Professor Department of Medicine, Harvard Medical School, Boston, Massachusetts
10/98-present Associate Professor Department of Internal Medicine, University of Iowa College of Medicine

V. Other Employment Pertaining to Current Professional Appointments

Year Position Institution
     
None    

VI. Certification and Licensure

A. Certification:

Board Date Number
American Board of Internal Medicine 9/13/89 123809
ABIM, Rheumatology 11/6/90 123809

B. Licensure:

State Date Perm./Temp Number Renewal Date
Massachusetts 1991 Perm 74456 4/8/00
Iowa 1998 Perm 32764 4/1/01

C. Other:

VII. Professional Affiliations (including offices held)

Year Organization
1975-1977 American Society of Parasitologists
1975-1988 Northern California Parasitological Society
1978-1985 Sutro Society
1994 American College of Rheumatology
1998 American Association of Immunologists
1998 American Society for Microbiology
2000 Central Society for Clinical Research

VIII. Areas of Research Interest

  1. Antigen Recognition by T Cells
  2. Nonpeptide Antigen Presentation to T Cells
  3. T Cell-mediated Immunity to Infection
  4. Adhesion and Chemotaxis of gd T cells

IX. Current Projects

  1. Recognition of nonpeptide ligands by human γδ T cells
  2. Novel pathway for autoimmune recognition by γδ T cells

X. Teaching Activities (Also See Section XI. Include activities of the last five years or since the time of last promotion.)

A. Classroom, Seminar, or Teaching Laboratory:


Year

Course Title
(% for which responsible)
     
1999 Advanced Topics in Immunology 33% (3 hr/wk
x 5 weeks)

B. Clinical Teaching (in ward, clinic, or operating room):

Year Where Teaching Occurred Wks/Yr Hrs/Wk
       
1986-1996 Introduction to Clinical Medicine: Rheumatology Exam, two medical students for two sessions/year, Harvard Medical School 2  
1999-present Preceptor for medical students/residents in clinic 12 2
1999-present Rheumatology consult attending for residents/fellows 3 40

XI. Teaching Activities - other than classroom or clinical, including teaching of under-graduate (pre-baccalaureate), graduate, and postdoctoral students and continuing education.

A.Conferences, Grand Rounds, Journal Clubs, Etc.:

Year Type of Activity Wks/Yr Hrs/Wk
1983 Rheumatology Grand Rounds, Division of Rheumatology, University of California, San Francisco, San Francisco, CA    
1991 Rheumatology Seminar, Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA    
1996 Microbiology/Immunology Seminar, Department of Microbiology/
Immunology and Division of Rheumatology, UCSF, San Francisco, CA
   
1996 Immunology Seminar, Committee on Immunology, University of Chicago, Chicago, IL    
1996 Immunology Seminar, Committee on Immunology, Washington University, St. Louis, MO    
1996 Rheumatology Grand Rounds, Division of Rheumatology, New England Medical Center, Boston, MA    
1996 Research Seminar, Division of Rheumatology and Immunology, Brigham and Women’s Hospital, Boston, MA    
1996 Immunology Seminar, Beth Israel Hospital, Boston, MA    
1996 Special Seminar, Basic Sciences and Department of Medicine, UC San Diego, San Diego, CA    
1996 Rheumatology Seminar, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA    
1996 Rheumatology Grand Rounds, Division of Rheumatology, University of Texas, Southwestern, Dallas, TX    
1997 Rheumatology Seminar, Division of Rheumatology, University of Illinois, Chicago, IL    
1997 Immunology Seminar, Center for Advanced Research in Biotechnology, University of Maryland, Gaithersburg, MD    
1997 Rheumatology Seminar, Division of Rheumatology, University of Utah, Salt Lake City, UT    
1997 Immunology Seminar, Rheumatology Grand Rounds, Committee on Immunology and Division of Rheumatology, University of Chicago, Chicago, IL    
1998 Immunology Seminar, Division of Rheumatology, University of San Francisco, San Francisco, CA    
1998 Immunology Seminar, Interdisciplinary Group in Immunology, University of Iowa, Iowa City, IA    
1998 Internal Medicine Research Seminar, Department of Internal Medicine, University of Iowa, Iowa City, IA    

B. Teaching Committees:

1. Student Counseling:

Megen Samelson, Summer Technician

2. Formal Study to Improve Teaching Abilities:

Attended "New Faculty Workshop", May 14, 1999, OCRME

C. Current Research:

D. Bibliography Concerning Teaching:

E. Other:

XII. Other Professional Activities (Boards, Editorships, Etc.)

Year Activity
1990 Ad hoc reviewer:
Journal of Immunology
Journal of Clinical Investigation
Arthritis and Rheumatism
International Immunology
Cellular Immunology
Clinical Immunology and Immunopathology
Molecular Medicine
Infection and Immunity
2000 Co-Editorship: Co-Editor with Michael B. Brenner, Springer Seminars in Immunopathology, "g d T Cells in Human Diseases", In preparation.

XIII. Clinical Activities

A. Inpatient:

Rheumatology consults 3 weeks/year

B. Outpatient:

University of Iowa Rheumatology Clinic - _1/2 day clinic per week
Veterans Hospital Rheumatology Clinic— _1/2 day clinic per month

C. Other:

XIV. Collegiate, University, University Hospitals, and National Committees

Year Committee

XV. Honors and Awards

XVI. Financial Resources (Grants and Contracts)

A. Federal:

Title Period Amount
     
NIH/K08 Clinical Investigator Award: "Recognition of nonpeptide ligands by human γδ T cells"
1995-01 $453,800 total
NIH/R03 Small Grant Award: "Novel pathway for autoimmune recognition by γδ T cells"
1997-00 $234,525 total
NIH/R01 "Antigen Recognition by Human g d T Cells"
1998-03 $1,190,949 total

B. State:

C. College of Medicine:

D. Other:

Title Period Amount
     
Leukemia Society of America
Special Fellowship: "Nonpeptide ligands and the recognition of Daudi and RPMI 8226 lymphoma by Human γδ T Cells"
1995 $3,000 total
ACR/Arthritis Foundation Postdoctoral Fellowship: "Recognition of Nonpeptide Ligands by Human γδ T Cells"
1992-1995 $91,500 total
Arthritis Foundation ACR Investigator: "Recognition of nonpeptide ligands by human γδ T cells"
1995-98 $210,000 total
Arthritis Foundation Biomedical Science Grant: "Recognition of nonpeptide antigens by human γδ T cells" 1998-01 $240,000 total

XVII. Physical Facilities

A. Office: 340F EMRB

B. Laboratory: 340E/J EMRB

C. Other:

XVIII. Personnel Currently Supervised

Pamela Bruellman, Research Assistant
John Edgar, Rotation Graduate Student

XIX. Masters' and Ph.D. Theses Directed and Postdoctoral Fellows Supervised

David Leslie, M.D., Pediatric Rheumatology Fellow Trained in research procedures, cell culture, research methodology, August, 1997 - February, 1998.

Elizabeth Märker-Hermann, M.D., Assistant Professor in Medicine, Trained in purification techniques, bacterial and cell culture while on sabbatical, February, 1998 - August, 1998.

Hoi K. Lee, Technician, Trained in research procedures, cell culture, research methodology, October, 1996 - August, 1999. Admitted to University of Iowa Medical School.

Anna C. Kemp, Technician, Trained in cell culture, research methodology, September, 1999 — January, 2000. Admitted to University of Iowa Medical School.

XX. Bibliography

A. Papers Published or In Press
    1. Siebert AE Jr, Blitz RR, Morita CT, Good AH. Taenia crassiceps: serum and surface immunoglobulins in metacestode infections of mice. Exp Parasitol 1981; 51:418.
    2. Char DH, Rand N, Howes EL Jr, Lyon H, Morita CT. Anti-retinoblastoma monoclonal antibodies. Retina 1983; 3:200.
    3. Char DH, Wood IS, Huhta K, R and N, Morita CT, Howes EL. Retinoblastoma: tissue culture lines and monoclonal antibody studies. Invest Ophthalmol Vis Sci 1984; 25:30.
    4. Morita CT, Goodman JW, Lewis GK. Arsonate-specific murine T cell clones. II. Delayed-type hypersensitivity induced by p-azobenzenearsonate-L-tyrosine (ABA-Tyr). J Immunol 1984; 134:2894.
    5. Morita CT, Godfrey WL, Goodman JW, Lewis GK. Arsonate-specific murine T cell clones. III. Correlation between clonotype expression and fine specificity for analogs of L-tyrosine-p-azobenzenearsonate. J Immunol 1986; 137:2139.
    6. Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB. Evidence for extrathymic changes in the TCR γδ repertoire. J Exp Med 1990; 171:1597.
    7. Morita CT, Verma S, Aparicio P, Martinez-A C, Spits H, Brenner MB. Functionally distinct subsets of human g/d T cells. Eur J Immunol 1991; 21:2999.
    8. Uyemura K, Deans RJ, Band H, Ohmen J, Panchamoorthy G, Morita CT, Rea TH, Modlin RL. Evidence for clonal selection of γδ T-cells in response to a human pathogen. J Exp Med 1991; 174:683.
    9. Panchamoorthy G, McLean J, Modlin RL, Morita CT, Ishikawa S, Brenner MB, Band H. A predominance of the T cell receptor Vg2/Vd2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition. J Immunol 1991; 147:3360.
    10. Porcelli S, Morita CT, Brenner MB. CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. Nature (Lond.) 1992; 360:593.
    11. Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT. Nonpeptide ligands for human γδ T cells. Proc Natl Acad Sci USA 1994; 91:8175.
    12. Morita CT, Parker CM, Brenner MB, Band H. T cell receptor usage and functional capabilities of human γδ T cells at birth. J Immunol 1994; 153:3979.
    13. Bukowski JF, Morita CT, Brenner MB. Recognition and destruction of virus-infected cells by human γδ CTL. J Immunol 1994; 153:5133.
    14. Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB. Recognition of a lipid antigen by CD1 restricted ab+ T cells. Nature (Lond.) 1994; 372:691.
    15. Bukowski JF*, Morita CT*, Tanaka Y, Bloom BR, Brenner MB, Band H. Vg2Vd2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J Immunol 1995; 154:998. (*authors contributed equally to this work)
    16. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature (Lond.) 1995; 375:155.
    17. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H., Bloom BR, Golan, DE, Brenner MB. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 1995; 3:495.
    18. Diacovo TG, Roth SJ, Morita CT, Rosat J-P, Brenner MB, Springer TA. Interactions of ab and γδ T lymphocyte subsets in shear flow with E-selectin and P-selectin. J Exp Med 1996; 183:1193.
    19. García VE, Sieling PA, Gong J-H, Barnes PF, Tanaka Y, Bloom BR, Morita CT, Modlin RL. Single cell cytokine analysis of γδ T cell responses to nonpeptide mycobacterial antigens. J Immunol 1997; 159:1328.
    20. Roth SJ, Diacovo TG, Rosat J-P, Buccola J, Brenner MB, Morita CT, Springer TA. Transendothelial chemotaxis of human a/b and g/d T lymphocytes to chemokines. Eur J Immunol 1998; 28:104.
    21. Bukowski JF, Morita CT, Band H, Brenner MB. Crucial role of TCRg chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells. J Immunol 1998; 161:286.
    22. García VE, Jullien D, Song M, Uyemura K, Shuai K, Morita CT, Modlin RL. IL-15 enhances the response of human g d T cells to nonpeptide microbial antigens. J Immunol 1998; 160:4322.
    23. García VE, Uyemura K, Sieling PA, Ochoa MT, Morita CT, Okamura H, Kurimoto M, Rhea TH, Modlin RL. IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection. J Immunol 1999; 162:6114.
    24. Bukowski JF, Morita CT, Brenner MB. Human g d T cells recognize alkylamines derived from tea, edible plants, and microbes: Implications for innate immunity. Immunity 1999; 11:57.
    25. Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB. Self recognition of CD1 by g d T cells: implications for innate immunity. J Exp Med 2000; 191:937.
    26. Bukowski JF, Roncarolo MG, Spits H, Krangel MS, Morita CT, Brenner MB, Band H. T-cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. Eur J Immunol. 2000; In press.

    B. Books and/or Chapters

  1. Morita CT, Scott DM, Goodman JW, Lewis GK. Characterization of molecules released by hapten immunized lymphocytes. In: Janeway CT, Sercarz EE, Wigzell H, eds. Immunoglobulin Idiotypes and Their Expression. New York: Academic Press. 1981.
  2. Char DH, Rand N, Howes EL Jr, Wood I, Lyon H, Morita CT. Anti-retinoblastoma monoclonal antibodies. In: Symposium on the Immunology and Immunophathology of the Eye. Masson Publishing Co. 1982.
  3. Morita CT. The Antigen Receptor of p-Azobenzenearsonate-L-Tyrosine-Reactive T Cells Mediating Delayed-Type Hypersensitivity: Idiotype Expression and Antigen Binding. Doctoral dissertation, Department of Microbiology and Immunology, University of California School of Medicine, San Francisco, CA 1985.

C. Abstracts

  1. Morita CT, Goodman JW, Lewis GK. Antigen binding molecules in DTH T-suppressor supernatants. J Supramolecular Structure and Cellular Biochemistry, Supplement 5:44. Workshop presentation at the ICN-UCLA Symposium on "Immunoglobulin Idiotypes and their Expression", February 1981.
  2. Morita CT, Hornbeck PV, Goodman JW, Lewis GK. In vivo effects of a monoclonal rat anti-CRI antibody: Differential effects on antibody versus delayed-type hypersensitivity responses to p-azobenzenearsonate. Immunobiology 163:419. Presented at the 15th International Leukocyte Culture Conference, December 1982.
  3. Morita CT, Goodman JW, Lewis GK. Monoclonal antibodies against the antigen receptors of ABA-Tyr reactive T cell clones. J Cellular Biochem Supplement 8A:203. Presented at the ICN-UCLA Symposium on "Regulation of the Immune System", March 1984.
  4. Band H., Panchamoorthy G, Morita CT, McLean J, Ishikawa S., Modlin RL, Brenner MB. Recognition of mycobacterial antigens by human g d T cells. Presented at the Fellows 40th Anniversary Conferance, June 1991.
  5. Morita CT, Band H, Panchamoorthy G, Brenner MB. A major subset of human g d T cells reactive to Mycobacterium tuberculosis is not restricted by classical MHC molecules. J Cellular Biochem Supplement 16D:68. Presented at the Keystone Symposium on "Antigen Presentation Functions of the MHC", March 1992.
  6. Morita CT, Band H, Panchamoorthy G, Brenner MB. A major subset of human g d T cells reactive to Mycobacterium tuberculosis is not restricted by classical MHC molecules. Poster presentation at the Arthritis Foundation Research Conferance, June 1993.
  7. Morita CT, Tanaka Y, Bukowski JF, Nieves E, Band H, Bloom BR, Brenner MB. Recognition of nonpeptide antigens by human g d T cells. J Cellular Biochem Supplement 21A:102. Workshop presentation at the Keystone Symposium on "Control and Manipulation of the Immune System", March 1995.
  8. Bukowski JF, Morita CT, Band H, Brenner MB. TCR-mediated recognition of activated T lymphocytes by human Vg 2Vd 2 T cells. J Cellular Biochem Supplement 21A:89. Poster presentation at the Keystone Symposium on "Control and Manipulation of the Immune System", March 1995.
  9. Morita CT, Beckman E, Bukowski JF, Tanaka Y, Band H, Golan DE, Bloom BR, Brenner MB. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human g d T cells. Abstract #1495. Workshop presentation at the 9th International Congress of Immunology, July 1995.
  10. Morita CT, Beckman E, Bukowski JF, Tanaka Y, Band H, Golan DE, Bloom BR, Brenner MB. The majority of human g d T cells recognize nonpeptide prenyl pyrophosphate antigens Abstract #485. Minisymposium presentation at the American College of Rheumatology National Scientific Meeting, October 1995. Arthritis and Rheumatism 1995; 38, (Suppl):S233.
  11. Morita CT, Beckman E, Bukowski JF, Tanaka Y, Band H, Golan DE, Bloom BR, Brenner MB. Extracellular presentation pathway for nonpeptide prenyl pyrophosphate antigens to human g d T cells. Poster presentation at the Arthritis Research Conference, NIH, June 1997.
  12. Morita CT, Lamphear JG, Casoratti G, Migone, N., Li H, Rich RR, Fraser JD, Mariuzza RA, Lee HK. Human g d T cell recognition of the superantigen SEA is distinct from the recognition of nonpeptide antigens: SEA binding site for human Vg 2 T cell receptors. Poster presentation at the American College of Rheumatology National Scientific Meeting, November 1997. Arthritis and Rheumatism 1997; 40, (Suppl).
  13. Llera A, Lebedeva M, Leder L, Morita C, Brenner M, Mariuzza R. Cloning and expression of a soluble human g d T cell receptor. Poster presentation at the Keystone Symposium on "T Lymphocyte Activation, Differentiation and Death" 1998.
  14. Morita CT, Lee HK, Tanaka Y. Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human g d T cells. Abstract #1315. Poster presentation at the American College of Rheumatology National Scientific Meeting, November 1998. Arthritis and Rheumatism 1998; 41, (Suppl):S252.
  15. Märker-Hermann E, Lee HK, Morita CT. Partial purification of the major Vg 2Vd 2 T lymphocyte antigen from Yersinia enterocolitica. Abstract #591. Workshop presentation at the American College of Rheumatology National Scientific Meeting, November 1998. Arthritis and Rheumatism 1998; 41, (Suppl):S131.
  16. Leslie DS, Lee HK, Spada F, Märker-Hermann E, Morita CT, Brenner MB. Recognition of lipid antigens by CD1b restricted g d T cells. Abstract #1311. Poster presentation at the American College of Rheumatology National Scientific Meeting, November 1998. Arthritis and Rheumatism 1998; 41, (Suppl):S251.
  17. Morita CT, Lee HK, Tanaka Y. Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human g d T cells. Workshop and poster presentation at the Autumn Immunology Conference, November 1998.
  18. Morita CT, Lee HK, Li H, Mariuzza RA, Tanaka Y. Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human g d T cells. Workshop presentation at the Arthritis Research Conference, August 1999
  19. Morita CT, Spada F, Grant EP, Peters PJ, Lee HK, Sugita M, Melian A, Krensky AM, Porcelli SA, Brenner MB. Major tissue g d T cell subset recognizes CD1c on professional antigen presenting cells. Abstract #3109. Poster presentation at the American College of Rheumatology National Scientific Meeting, November 1999. Arthritis and Rheumatism 1999; 42, (Suppl):S.
  20. Bukowski JF, Morita CT, Brenner MB. Human g d T cells recognize alkylamines derived from tea beverage, edible plants, and microbes: Implications for innate immunity. Abstract #3109. Poster presentation at the American College of Rheumatology National Scientific Meeting, November 1999. Arthritis and Rheumatism 1999; 42, (Suppl):S259.
  21. Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB. Self recognition of CD1 by g d T cells: Implications for innate immunity. Workshop presentation by Dr. Spada at the Keystone Symposium on "Determinants of Immune Defense Against Microbial Infections" 2000.

D. Reviews

  1. Band, H, Panchamoorthy G, McLean J, Morita CT, Ishikawa S, Modlin R, and Brenner MB. Recognition of mycobacterial antigens by γδ T cells. In: "25th Forum in Immunology" (F. Plata). Res Immunol 1990; 141:645.
  2. Band H, Porcelli SA, Panchammorthy G, McLean J, Morita CT, Ishikawa S, Modlin RL, Brenner MB. Antigens and antigen-presenting molecules for γδ T cells. Curr Topics Micro Immunol 1991; 173:229.
  3. Tanaka Y, Brenner MB, Bloom BR, Morita CT. Recognition of nonpeptide antigens by T cells. J Mol Med 1996; 74:223.
  4. Morita CT, Tanaka Y, Bloom BR, Brenner MB. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. In "66th Forum in Immunology" (F. Plata). Res Immunol 1996; 147:73.
  5. Porcelli SA, Morita CT, Modlin RL. T-cell recognition of non-peptide antigens. Curr Opin Immunol 1996; 8:510.
  6. Chu DA, Morita CT, Weiss A. The Syk family of protein tyrosine kinases in T cell activation and development. Immunol. Reviews 1998; 165:167.
  7. Morita CT, Lee HK, Leslie DS, Tanaka Y, Bukowski JF, Märker-Hermann E. Recognition of nonpeptide prenyl pyrophosphate antigens by human g d T cells. Microbes and Infection 1999; 1:175.
  8. Morita CT, Mariuzza, RA, Brenner, MB. Antigen recognition by human γδ T cells: Pattern recognition by the adaptive immune system. Springer Sem Immunopath 2000; In press.

E. Other: Exhibits, Films, Tapes, Special Presentations

  1. Rheumatology Grand Rounds, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 1983.
  2. Rheumatology Seminar, Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 1991.
  3. Workshop Speaker, Keystone Symposia Immunity to Microorganisms, Taos, New Mexico, 1995.
  4. Workshop Speaker, 9th International Congress of Immunology, San Francisco, CA, 1995.
  5. Speaker, Minisymposium on Signal Transduction, American College of Rheumatology National Meeting, San Francisco, CA, 1995.
  6. Microbiology/Immunology Seminar, Department of Microbiology/
    Immunology and Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 1996.
  7. Immunology Seminar, Committee on Immunology, University of Chicago, Chicago, IL, 1996.
  8. Immunology Seminar, Committee on Immunology, Washington University in St. Louis, St. Louis, MO, 1996.
  9. Research Seminar, Monsanto-Searle, St Louis, MO, 1996.
  10. Rheumatology Grand Rounds, Division of Rheumatology, New England Medical Center, Boston, MA, 1996.
  11. Immunology Seminar, Beth Israel Hospital, Boston, MA, 1996.
  12. Special Seminar, Basic Sciences and Department of Medicine, University of California, San Diego, San Diego, CA, 1996.
  13. Rheumatology Seminar, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 1996.
  14. Rheumatology Grand Rounds, Division of Rheumatology, University of Texas, Southwestern, Dallas, TX, 1996.
  15. Immunology Seminar, Center for Advanced Research in Biotechnology, University of Maryland, Rockville, MD, 1997.
  16. Rheumatology Seminar, Division of Rheumatology, University of Utah, UT, 1997
  17. Invited Speaker, Workshop on Peptide Antagonists and non classical TCR ligands, 13th European Immunology Meeting, Amsterdam, The Netherlands, 1997
  18. Rheumatology Seminar, Division of Rheumatology, University of Illinois, Chicago, IL, 1997.
  19. Immunology Seminar, Rheumatology Grand Rounds, Committee on Immunology and Division of Rheumatology, University of Chicago, Chicago, IL, 1997.
  20. Immunology Seminar, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 1998.
  21. Internal Medicine Seminar, Division of Rheumatology, University of Iowa, Iowa City, IA, 1998.
  22. Immunology Seminar, Program in Immunology, University of Iowa, Iowa City, IA, 1998.
  23. Invited Speaker, Workshop on Recognition and Response: Regulation of the Antigen Receptor, Arthritis Research Conference, Alexandria, VA, 1999.

F. Papers Submitted or In Preparation

  1. Morita CT, Lamphear JG, Li H, Rich RR, Fraser JD, Mariuzza RA, Lee HK. Recognition of superantigens by g d T cells: SEA recognition site for human Vg 2 T cell receptors. Manuscript submitted for publication.
  2. Tanaka Y, Hua Z, Morita CT, Uchiyama T. Fine antigen specificity and tumoricidal activity of human g d T cells. Manuscript submitted for publication
  3. Morita CT, Lee HK, Li H, Bloom BR, Mariuzza RA, Tanaka Y. Structural features of prenyl pyrophosphates that determine their antigenicity for g d T cells. Manuscript in preparation.

XXI. Other Comments