The University of Iowa Carver College of Medicine

Electron Spin Resonance Facility

Free Radicals in Biology

The following papers were generated by students from Graduate Course Free Radicals in Biology and Medicine (77:222) 2003.

Instructors

  • Garry R. Buettner, Ph.D.
  • Larry W. Oberley, Ph.D.

Please Note

In view of the possibility of human error or changes in our knowledge due to continued research, neither the authors nor The University of Iowa nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirmthe information contained herein with other sources.

All material contained in these papers is copyright of the papers' author, or the owner of the source that the material was taken from. These works are not intended as threats to the ownership of said copyrights.

Paper 1

  Author Title  pdf 
Chauhan, Gaurav Phenoxyl Radicals: Flavonoids
pdf available
Fisher, Carolyn Lipid Hydroperoxide (LOOH) of the Fatty Acid (FA) Nature
pdf available
Gao, Zhen Hydroxyl Radical and Its Detection Methods pdf available
Hamsakutty, Harris Nitrogen Dioxide Radical pdf available
Hu, Sharon Hydroxyl Radical pdf available
Krager, Kim Superoxide in Aprotic Solvents pdf available
Li, Hualei Lipid Alkoxyl Radicals pdf available
Liu, Jingru Protein Hydroperoxides ( POOH ) pdf available
Menon, Sarita Nitrosoperoxocarboxylate pdf available
Niu, Gang Hypochlorous Acid pdf available
Rodionov, Roman Chemistry of peroxynitrite in biological systems pdf available
Sarsour, Ehab Nitroxyl (HNO/NO-) not Nitric Oxide (NO·) pdf available
Slane, Benjamin CoQ Semiquinone Radical pdf available
Xiao, Ling Lipid Hydroperoxide (LOOH) pdf available
Yu, Lei Ozone, Bad guy or good guy? pdf available
Zheng, Xiaomei Tocopheroxyl Radical pdf available
Zimmerman, Matthew Sulfenic Acids: An Overview pdf available

Paper 2

  Author Title  pdf 
Chauhan, Gaurav Diethylenetriaminepentaacetic acid (DTPA): A metal chelating agent
pdf available
Fisher, Carolyn Organoselenium Compounds as Glutathione Peroxidase Mimics
pdf available
Gao, Zhen The Anti-Oxidant Effects of Nitric Oxide pdf available
Hamsakutty, Harris Cysteine pdf available
Hu, Sharon Is Zinc an Antioxidant ?
pdf available
Krager, Kim Bilirubin pdf available
Li, Hualei Pyruvate, a Sacrificial Antioxidant pdf available
Liu, Jingru NADPH pdf available
Menon, Sarita N-Acetyl-L-Cysteine pdf available
Niu, Gang Vitamin K pdf available
Rodionov, Roman Urate as an endogenous antioxidant pdf available
Sarsour, Ehab Desferal® pdf available
Slane, Benjamin Liopoic Acid pdf available
Xiao, Ling Desferrioxamine (DFO) pdf available
Yu, Lei Glutathione, why we need it every day? pdf available
Zheng, Xiaomei a-Tocopherol, Lipid Antioxidant pdf available
Zimmerman, Matthew Nitric Oxide: An Antioxidant pdf available

Paper 3

  Author Title  pdf 
Chauhan, Gaurav Glutathione S-transferases: Family of enzymes
pdf available
Fisher, Carolyn Melanin: The Pigmented Truth
pdf available
Gao, Zhen The Nuclear Factor - kB pdf available
Hamsakutty, Harris Heme Oxygenase pdf available
Hu, Sharon The Role of p53 in the Redox Modulation in the DNA Binding pdf available
Krager, Kim Heat Shock Protein 90: The Shock Absorber
pdf available
Li, Hualei OxyR, a Redox-operated Switch pdf available
Liu, Jingru Classic Glutathione Peroxidase pdf available
Menon, Sarita Peroxiredoxins pdf available
Niu, Gang Myeloperoxidase pdf available
Rodionov, Roman Endothelial Nitric Oxide Synthase pdf available
Sarsour, Ehab Hypoxia-inducible factor 1 (HIF-1) pdf available
Slane, Benjamin Thioredoxin: a family conserved pdf available
Xiao, Ling Thioredoxin Reductase (TrxR) pdf available
Yu, Lei NF- kB, a redox regulated transcription factor pdf available
Zheng, Xiaomei Extracellular Superoxide Dismutase pdf available
Zimmerman, Matthew NADPH Oxidase pdf available

Paper 4

  Author Title  pdf 
Chauhan, Gaurav Selenium: The essential poison
pdf available
Fisher, Carolyn Streptozocin
pdf available
Gao, Zhen The Toxicology of Carbon Tetrachloride pdf available
Hamsakutty, Harris Adriamycin pdf available
Hu, Sharon Paraquat toxicity pdf available
Krager, Kim Just Sit Back and Relax with Sodium Nitroprusside pdf available
Li, Hualei Dithiothreitol (Cleland's Reagent) pdf available
Liu, Jingru 1,3-bis-Chloroethyl-1-Nitrosourea (BCNU) pdf available
Menon, Sarita Motexafin Gadolinium pdf available
Niu, Gang Bleomycin pdf available
Rodionov, Roman Nitroglycerin pdf available
Sarsour, Ehab Acetaminophen pdf available
Slane, Benjamin Antimycin: the big bad chain blocker pdf available
Xiao, Ling Buthionine Sulfoximine ( BSO ) pdf available
Yu, Lei Ultraviolet Radiation pdf available
Zheng, Xiaomei Cigarette Smoke pdf available
Zimmerman, Matthew Streptozocin pdf available

Paper 5

  Author Title  pdf 
Chauhan, Gaurav Sickle-cell anemia
pdf available
Fisher, Carolyn Parkinson's Disease: A Review
pdf available
Gao, Zhen Free Radicals in the Rheumatoid Arthritis pdf available
Hamsakutty, Harris Radiation-Induced Fibrosis pdf available
Hu, Sharon ALS pdf available
Krager, Kim Alcoholism pdf available
Li, Hualei Free Radicals and Cataract pdf available
Liu, Jingru Oxidative Stress in Parkinson's disease pdf available
Menon, Sarita Exploiting redox regulation of cell cycle for novel breast cancer therapeutics pdf available
Niu, Gang Free Radical in Ischemia/reperfusion Injury pdf available
Rodionov, Roman The roles of free radicals in the pathogenesis of atherosclerosis pdf available
Sarsour, Ehab Aging: The role of MnSOD in life span extension through cell cycle and telomeres maintenance  
Slane, Benjamin Leigh's Syndrome pdf available
Xiao, Ling Oxidative Stress and Diabetes pdf available
Yu, Lei Inflammation and oxidative stress pdf available
Zheng, Xiaomei Cancer pdf available
Zimmerman, Matthew Central Angiotensin II-Dependent Hypertension:
A Role for Reactive Oxygen Species
pdf available

Appendix

  Author Title  pdf 
Buettner, Garry R. The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, a-Tocopherol, and Ascorbate Arch Biochem Biophys 1993, 300: 535-543 pdf available
Schafer, Freya Q. et al. Redox Environment of the Cell as Viewed through the Redox State of the Glutathione Disulfide/Glutathione Couple Free Radic Biol Med 2001, 30: 1191-1212 pdf available
Hempel, Stephen L. et al. Dihydrofluorescein Diacetate Is Superior for Detecting Intracellular Oxidants: Comparison with 2',7'- Dichlorodihydrofluorescein Diacetate, 5(and 6)-Carboxy-2',7'-Dichlorodihydrofluorescein Diacetate, and Dihydrorhodamine 123 Free Radic Biol Med 1999, 27: 146-159 pdf available
Qian, Steven Yue et al. Iron and Dioxygen Chemistry Is an Important Route to Initiation of Biological Free Radical Oxidations: An Electron Paramagnetic Resonance Spin Trapping Study Free Radic Biol Med 1999, 26: 1447-1456 pdf available
Venkataraman, Sujatha et al. Detailed Methods for the Quantification of Nitric Oxide in Aqueous Solutions Using Either an Oxygen Monitor or EPR Free Radic Biol Med 2000, 29: 580-585 pdf available
Kelley, Eric E. et al. Relative a-Tocopherol Deficiency in Cultured Cells: Free Radical-Mediated Lipid Peroxidation, Lipid Oxidizability, and Cellular Polyunsaturated Fatty Acid Content Arch Biochem Biophys 1995, 319: 102-109 pdf available
Wagner, Brett A. et al. Vitamin E Slows the Rate of Free Radical-Mediated Lipid Peroxidation in Cells Arch Biochem Biophys 1996, 334: 261-267 pdf available